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Semin Thromb Hemost 2010; 36(5): 493-497
DOI: 10.1055/s-0030-1255443
© Thieme Medical Publishers

Recombinant Factor VIII Concentrates

Massimo Franchini1 , Giuseppe Lippi2
  • 1Servizio di Immunoematologia e Medicina Trasfusionale, Dipartimento di Patologia e Medicina di Laboratorio, Azienda Ospedaliero-Universitaria di Parma, Parma, Italy
  • 2U.O. di Diagnostica Ematochimica, Azienda Ospedaliero-Universitaria di Parma, Parma, Italy
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Publication History

Publication Date:
14 July 2010 (online)

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ABSTRACT

The development and introduction of recombinant factor VIII (rFVIII) concentrates nearly 20 years ago represented a major advance in the treatment of hemophilia A patients. Currently, first-, second- and third-generation rFVIII products are commercially available. Whereas first-generation rFVIII concentrates are stabilized with human albumin, second-generation rFVIII products contain sucrose instead of albumin in the final formulation. Finally, third-generation rFVIII products are manufactured without additional human or animal plasma proteins. The use of rFVIII concentrates has greatly improved the safety of replacement therapy in hemophilia A and virtually abolished the risk of blood-borne pathogen transmission. The remaining and most challenging aspect of hemophilia A management has now become the development of FVIII inhibitors. In this article we review the current knowledge on the commercially available rFVIII concentrates, analyzing their main characteristics. Moreover, results of the literature on their clinical hemostatic efficacy and safety are summarized.

KEYWORDS

rFVIII - bleeding - hemophilia - inhibitors

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Massimo FranchiniM.D. 

Servizio di Immunoematologia e Trasfusione

Azienda Ospedaliero-Universitaria di Parma, Parma, Italy

Email: massimo.franchini@azosp.vr.it