Abstract
Cardiac computed tomography (CT) allows for non-invasive evaluation of the coronary arteries. Coronary calcium is a measure of coronary atherosclerosis. Determining coronary calcium by using CT is useful for further risk stratification if the Framingham risk score defines an intermediate cardiovascular risk ranging between (6 - )10 % and 20 % in 10 years. In this case, many subjects’ risk can be reclassified on the basis of the calcium score, and the intensity of risk factor treatment can be adapted accordingly. Non-invasive coronary CT angiography (CTA) is a highly sensitive tool for detecting significant coronary stenoses. As opposed to the luminogram obtained with invasive coronary angiography, CTA also defines plaque build-up in the coronary wall. This occasionally results in an overestimation of stenosis severity. However, the negative predictive value is high, providing for the ability to rule out significant stenoses with a high degree of certainty.
Literatur
-
1
Agatston A S, Janowitz W R, Hildner F J et al.
Quantification of coronary artery calcium using ultrafast computed tomography.
J Am Coll Cardiol.
1990;
15
827-832
-
2
McClelland R L, Chung H, Detrano R et al.
Distribution of coronary artery calcium by race, gender, and age: results from the Multi-Ethnic Study of Atherosclerosis (MESA).
Circulation.
2006;
113
30-37
-
3
Schmermund A, Möhlenkamp S, Berenbein S et al.
Population-based assessment of subclinical coronary atherosclerosis using electron-beam computed tomography.
Atherosclerosis.
2006;
185
177-182
-
4
Detrano R, Guerci A D, Carr J J et al.
Coronary calcium as a predictor of coronary events in four racial or ethnic groups.
N Engl J Med.
2008;
358
1336-1345
-
5
Erbel R, Möhlenkamp S, Moebus S et al.
Coronary risk stratification, discrimination, and reclassification improvement based on quantification of subclinical coronary atherosclerosis: the Heinz Nixdorf Recall study.
J Am Coll Cardiol.
2010;
56
1397-1406
-
6
Folsom A R, Kronmal R A, Detrano R C et al.
Coronary artery calcification compared with carotid intima-media thickness in the prediction of cardiovascular disease incidence: the Multi-Ethnic Study of Atherosclerosis (MESA).
Arch Intern Med.
2008;
168
1333-1339
-
7
Rozanski A, Gransar H, Shaw L J et al.
Impact of coronary artery calcium scanning on coronary risk factors and downstream testing – The EISNER (Early Identification of Subclinical Atherosclerosis by Noninvasive Imaging Research) prospective randomized trial.
J Am Coll Cardiol.
2011;
57
1622-1632
-
8
Greenland P, Alpert J S, Beller G A et al.
American College of Cardiology Foundation; American Heart Association. 2010 ACCF/AHA guideline for assessment of cardiovascular risk in asymptomatic adults: a report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines.
J Am Coll Cardiol.
2010;
56
50-103
-
9
Budoff M J, Hokanson J E, Nasir K et al.
Progression of coronary artery calcium predicts all-cause mortality.
JACC Cardiovasc Imaging.
2010;
3
1229-1236
-
10
Polonsky T S, McClelland R L, Jorgensen N W et al.
Coronary artery calcium score and risk classification for coronary heart disease prediction.
JAMA.
2010;
303
1610-1616
-
11
Erbel R, Möhlenkamp S, Lehmann N et al.
Kardiovaskuläre Risikofaktoren und Zeichen subklinischer Atherosklerose.
Dtsch Arztebl.
2008;
105(1–2)
1-8
-
12
Miller J M, Rochitte C E, Dewey M et al.
Diagnostic performance of coronary angiography by 64-row CT.
N Engl J Med.
2008;
359
2324-2336
-
13
Achenbach S, Marwan M, Ropers D et al.
Coronary computed tomography angiography with a consistent dose below 1mSv using prospectively electrocardiogram-triggered high-pitch spiral acquisition.
Eur Heart J.
2010;
31
340-346
-
14
Einstein A J, Moser K W, Thompson R C et al.
Radiation dose to patients from cardiac diagnostic imaging.
Circulation.
2007;
116
1290-1305
-
15
Blankstein R, Shturman L D, Rogers I S et al.
Adenosine-induced stress myocardial perfusion imaging using dual-source cardiac computed tomography.
J Am Coll Cardiol.
2009;
54
1072-1084
-
16
Budoff M J, Achenbach S, Blumenthal R S et al.
Assessment of coronary artery disease by cardiac computed tomography: a scientific statement from the American Heart Association Committee on Cardiovascular Imaging and Intervention, Council on Cardiovascular Radiology and Intervention, and Committee on Cardiac Imaging, Council on Clinical Cardiology.
Circulation.
2006;
114
1761-1791
-
17
Mark D B, Berman D S, Budoff M J et al.
ACCF/ACR/AHA/NASCI/SAIP/SCAI/SCCT 2010 expert consensus document on coronary computed tomographic angiography: a report of the American College of Cardiology Foundation Task Force on Expert Consensus Documents.
J Am Coll Cardiol.
2010;
55
2663-2699
-
18 . http://www.khk.versorgungsleitlinien.de [Zugriff: 2.5.2011]
-
19
Chow B J, Abraham A, Wells G A et al.
Diagnostic accuracy and impact of computed tomographic coronary angiography on utilization of invasive coronary angiography.
Circ Cardiovasc Imaging.
2009;
2
16-23
-
20
Hulten E A, Carbonaro S, Petrillo S P et al.
Prognostic value of cardiac computed tomography angiography: a systematic review and meta-analysis.
J Am Coll Cardiol.
2011;
57
1237-1247
-
21
Hoffmann U, Bamberg F, Chae C U et al.
Coronary computed tomography angiography for early triage of patients with acute chest pain: the ROMICAT (Rule Out Myocardial Infarction using Computer Assisted Tomography) trial.
J Am Coll Cardiol.
2009;
53
1642-1650
-
22
Andreini D, Pontone G, Mushtaq S et al.
Multidetector computed tomography coronary angiography for the assessment of coronary in-stent restenosis.
Am J Cardiol.
2010;
105
645-655
-
23
Von Ballmoos M W, Haring B, Juillerat P, Alkadhi H.
Meta-analysis: diagnostic performance of low-radiation-dose coronary computed tomography angiography.
Ann Intern Med.
2011;
154
413-420
-
24
Perisinakis K, Seimenis I, Tzedakis A et al.
Individualized assessment of radiation dose in patients undergoing coronary computed tomographic angiography with 256-slice scanning.
Circulation.
2010;
122
2394-2402
Prof. Dr. Axel SchmermundFESC
Cardioangiologisches Centrum Bethanien, CCB
Im Prüfling 23
60389 Frankfurt
eMail: A.Schmermund@ccb.de
Dr. med. Annett Magedanz
Cardioangiologisches Centrum Bethanien, CCB
Im Prüfling 23
60389 Frankfurt
eMail: A.Magedanz@ccb.de
Dr. med. Marco Schmidt
Cardioangiologisches Centrum Bethanien, CCB
Im Prüfling 23
60389 Frankfurt
eMail: M.Schmidt@ccb.de
Prof. Dr. Bernd Nowak
Cardioangiologisches Centrum Bethanien, CCB
Im Prüfling 23
60389 Frankfurt
eMail: B.Nowak@ccb.de
PD Dr. med. Thomas Voigtländer
Cardioangiologisches Centrum Bethanien, CCB
Im Prüfling 23
60389 Frankfurt
eMail: T.Voigtlaender@ccb.de