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Synthesis 2010(19): 3346-3352  
DOI: 10.1055/s-0030-1257910
PAPER
© Georg Thieme Verlag Stuttgart ˙ New York

Synthesis of Novel Furo-, Thieno-, and Pyrroloazepines

Carlos Villarreal, Roberto Martínez*
Instituto de Química, Universidad Nacional Autónoma de México, Circuito Exterior S. N., Ciudad Universitaria, México D. F. 04510, México
e-Mail: robmar@servidor.unam.mx;
Further Information

Publication History

Received 23 April 2010
Publication Date:
30 July 2010 (online)

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Abstract

The synthesis of novel furo-, thieno-, and pyrroloazepine compounds, using the oxidative radical alkylation of three five-membered heterocyclic 3-acetic acid derivatives, is described. The bicyclic systems were obtained, via a small number of steps, directly from commercially available materials.

Key words

oxidative radicals - carboxylic acid homologation - ­furan - thiophene - pyrrole - azepinones

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