The Sandmeyer Reaction on Some
Selected Heterocyclic Ring Systems: Synthesis of Useful
2-Chloroheterocyclic-3-carbonitrile Intermediates

Daniel da Silva; Abdelouahid Samadi; Mourad Chioua; Maria do Carmo Carreiras; José Marco-Contelles

doi:10.1055/s-0030-1258149

PAPER

The Sandmeyer Reaction on Some Selected Heterocyclic Ring Systems: Synthesis of Useful 2-Chloroheterocyclic-3-carbonitrile Intermediates

Daniel da Silva^a,b, Abdelouahid Samadi*^a, Mourad Chioua^a, Maria do Carmo Carreiras^b, José Marco-Contelles*^a
^a Laboratorio de Radicales Libres y Química Computacional (LRL/QC), IQOG (CSIC), C/Juan de la Cierva 3, 28006 Madrid, Spain
Fax: +33(91)5622900; Fax: +34(91)5644853; e-Mail: samadi@iqog.csic.es; e-Mail: iqoc21@iqog.csic.es;
^b iMEd.UL, Research Institute for Medicines and Pharmaceutical Sciences, Fac. Pharmacy, Univ. Lisbon, Av. Forças Armadas, 1600-083 Lisbon, Portugal

Abstract

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Abstract

The Sandmeyer reaction on some selected heterocycles bearing the 2-amino-3-carbonitrile structural moiety has been investigated in order to prepare the corresponding 2-chloro-3-carbonitrile derivatives as synthetic useful intermediates for further development.

Key words

Sandmeyer reaction - 2-amino(heterocyclic)-3-carbonitriles - 2-aminopyrazoles - 2-aminooxazoles - 2-amino-4H-pyrans - 2-amino-1,4-dihydropyridines - 2-aminopyridines - 2-chloro(heterocyclic)-3-carbonitriles

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References

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