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Synthesis 2010(22): 3883-3890
DOI: 10.1055/s-0030-1258263
DOI: 10.1055/s-0030-1258263
PAPER
© Georg Thieme Verlag
Stuttgart ˙ New York
Synthesis of Enantiomerically Pure 2,5-Disubstituted 3-Oxygenated Tetrahydrofurans
Further Information
Received
26 July 2010
Publication Date:
22 September 2010 (online)
Publication History
Publication Date:
22 September 2010 (online)
![](https://www.thieme-connect.de/media/synthesis/201022/lookinside/thumbnails/10.1055-s-0030-1258263-1.jpg)
Abstract
The synthesis of enantiomerically pure 2,5-disubstituted 3-oxygenated tetrahydrofurans has been achieved from cheap and commercially available l-malic acid. This method was used to prepare an advanced intermediate toward CMI-977, a promising candidate for the treatment of chronic asthma.
Key words
furan - tetrahydrofuran - singlet oxygen - butenolide - oxacycles - natural products
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