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Synthesis 2011(5): 755-758
DOI: 10.1055/s-0030-1258418
DOI: 10.1055/s-0030-1258418
PAPER
© Georg Thieme Verlag
Stuttgart ˙ New York
Stereoselective Formal Total Synthesis of (-)-Swainsonine from Garner’s Aldehyde
Further Information
Received
2 December 2010
Publication Date:
21 January 2011 (online)
Publication History
Publication Date:
21 January 2011 (online)
Abstract
A simple and facile stereoselective formal total synthesis of (-)-swainsonine has been reported starting from Garner’s l-serine derived oxazolidine aldehyde. Our synthetic strategy involves stereoselective allylation and Still olefination as key intermediary reaction steps.
Key words
swainsonine - indium - allylation - Garner’s aldehyde - Still olefination - indolizidine alkaloid
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