Abstract
A practical one-pot C-H activation/borylation/oxidation
sequence for the generation of 3,5-disubstituted phenols is presented. Specifically,
3-bromo-5-methylphenol is prepared from 3-bromotoluene, without
isolation of intermediates, on a multigram scale, and in high yield.
The process proceeds under mild conditions and can be completed
within one day.
Key words
phenol - C-H activation - borylation - oxidation - boronic ester
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