Two highly versatile isoxazoline derivatives, as key intermediates
for the synthesis of differently functionalized subtype-selective N-methyl-d-aspartate
receptor antagonists, were designed and synthesized. The synthetic
strategy is based on an intramolecular nitrile oxide cycloaddition
reaction which is a powerful method capable of controlling both
the regio- and stereochemistry of the pericyclic reaction.
N-methyl-d-aspartate
receptor antagonist - intramolecular nitrile oxide cycloaddition - regioselective - isoxazoline - amino acids
