Synlett 2010(17): 2601-2606  
DOI: 10.1055/s-0030-1258774
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© Georg Thieme Verlag Stuttgart ˙ New York

Facile Catalytic SNAr Reaction of Nonactivated Fluoroarenes with Amines Using η6-Benzene Ruthenium(II) Complex

Maiko Otsukaa, Hiroya Yokoyamaa, Kohei Endob, Takanori Shibata*a
a Department of Chemistry and Biochemistry, School of Advanced Science and Engineering, Waseda University, Okubo, Shinjuku, Tokyo 169-8555, Japan
b Waseda Institute for Advanced Study, Nishiwaseda, Shinjuku, Tokyo 169-8050, Japan
Fax: +81(3)52868098; e-Mail: tshibata@waseda.jp;
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Publication History

Received 30 July 2010
Publication Date:
30 September 2010 (online)

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Abstract

Catalytic SNAr reaction of fluoroarenes possessing no electron-withdrawing group(s) with cyclic amines was achieved using a readily accessible Ru catalyst, which was prepared from [Ru(benzene)Cl2]2, AgOTf, and P(p-FC6H4)3. The coexistence of molecular sieves MS4A realized high conversion and various substituted aryl amines were obtained in good to high yields.

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