Synthesis of Monofluoroalkenes via the Activation of Allylic C-F Bonds: A Novel Route to β-Aminofluoroalkenes Using Pd-Catalyzed Allylic Amination Reactions of 3,3-Difluoropropenes

Abstract

This article portrays the development of a novel and efficient synthetic route to β-aminofluoroalkenes, from readily available 3,3-difluoropropenes and amines, that proceeds via the activation of an allylic C-F bond.

C-F activation - organofluorine chemistry - fluoroal­kenes - palladium - homogeneous catalysis

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