Synthesis of a Novel Series
of 1,2,3-Triazole-Containing Artemisinin Dimers with Potent Anticancer
Activity Involving Huisgen 1,3-Dipolar Cycloaddition Reaction

Bishwajit Saikia; Partha Pratim Saikia; Abhishek Goswami; Nabin C. Barua; Ajit K. Saxena; Nitasha Suri

doi:10.1055/s-0030-1260157

PAPER

Synthesis of a Novel Series of 1,2,3-Triazole-Containing Artemisinin Dimers with Potent Anticancer Activity Involving Huisgen 1,3-Dipolar Cycloaddition Reaction

Bishwajit Saikia^a, Partha Pratim Saikia^a, Abhishek Goswami^a, Nabin C. Barua*^a, Ajit K. Saxena^b, Nitasha Suri^b
^a Natural Products Chemistry Division, CSIR-North-East Institute of Science & Technology, Jorhat 785006, Assam, India
^b Pharmacology Division, Indian Institute of Integrative Medicine, Jammu 180001, India
Fax: +91(376)2370011; e-Mail: ncbarua12@rediffmail.com;

Abstract

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Abstract

A series of C-10 acetal triazolylartemisinin dimers were prepared via the Huisgen 1,3-dipolar cylcoaddition of artemisinin-derived terminal alkynes with 10α-azidoartemisinin and various aliphatic and aromatic diazides. All the artemisinin dimers synthesized exhibited strong growth inhibition activity against several cancer cell lines.

Key words

artemisinin - Artemisia annua - antimalarial - 1,2,3-triazole - artemisinin dimer

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