Abstract
Heterocyclization reactions between N- arylmaleimides and
6-aminouracils were studied in detail. It was established that several
directions are possible depending on the nature of reaction medium
and the substituent character in the uracil component. The synthetic
procedure leading to N- phenyl-2,4,7-trioxopyrido[2,3-d ]pyrimidine-5-carboxamides
in good-to-high yields was developed and key stages of the corresponding
reaction were established.
Key words
heterocycles - nucleophilic addition - ring
opening - pyridines - pyrroles - annulation - regioselectivity
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