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Synthesis 2011(20): 3220-3224
DOI: 10.1055/s-0030-1260172
DOI: 10.1055/s-0030-1260172
PAPER
© Georg Thieme Verlag
Stuttgart ˙ New York
Synthesis of 2-(1H-1,2,3-Triazol-1-yl)-1,4-naphthoquinones from 2-Azido-1,4-naphthoquinone and Terminal Alkynes
Further Information
Received
24 May 2011
Publication Date:
16 August 2011 (online)
Publication History
Publication Date:
16 August 2011 (online)
Abstract
A series of 2-[(4-substituted 1H-1,2,3-triazol-1-yl)-1,4-naphthoquinones were prepared in moderate-to-good yields (51-90%) by the reaction of 2-azido-1,4-naphthoquinone with terminal alkynes in the presence of a catalytic amounts of copper(I) iodide in acetonitrile.
Key words
quinones - triazoles - heterocycles - copper catalysis - cycloaddition - alkynes - click chemistry
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