Abstract
Non-Schotten-Baumann conditions are described for the hydantoin-free
synthesis of peptide ester isocyanates using activated zinc dust
as a non-basic HCl scavenger. Also, the procedure gives no N-acylated
products in the case of the conversion of amino acid and peptide
amides into isocyanates.
Key words
zinc dust - peptide ester isocyanates - isothiocyanates - base-free synthesis - peptidyl ureas - thioureas
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