Abstract
The ability of a chiral isothiourea to promote the regio- and
enantioselective O- to C-carboxyl transfer of a series of 3-alkyl-5-aryl-
and 5-methyl-3-phenylfuranyl carbonates is examined, generating
preferentially the α-regioisomers (α/γ up
to 83:17) with high asymmetric induction (up to 83% ee).
Key words
isothiourea - organocatalysis - carboxyl transfer - furanyl carbonates - butenolides
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(R )-TADMAP gave a 60:40 mixture of α/γ regioisomers,
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