Microwave-Assisted Synthesis
of 5-Substituted 2-Aminothiophenes Starting from Arylacetaldehydes

Germain Revelant; Sandrine Dunand; Stéphanie Hesse; Gilbert Kirsch

doi:10.1055/s-0030-1261032

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Synthesis 2011(18): 2935-2940
DOI: 10.1055/s-0030-1261032

PAPER

Microwave-Assisted Synthesis of 5-Substituted 2-Aminothiophenes Starting from Arylacetaldehydes

Germain Revelant, Sandrine Dunand, Stéphanie Hesse*, Gilbert Kirsch
Laboratoire d’Ingénierie Moléculaire et Biochimie Pharmacologique, Institut Jean Barriol, FR CNRS 2843, 1 Boulevard Arago, 57070 Metz, France
Fax: +33(3)87325801; e-Mail: hesse@univ-metz.fr;

Further Information

Publication History

Received 29 April 2011
Publication Date:
05 August 2011 (online)

Abstract
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Abstract

An easy three-step pathway for the synthesis of arylacetaldehydes from the corresponding carboxylic acids in very high yields is described. Their use as precursors of 5-substituted-2-aminothiophenes is illustrated via a microwave-assisted Gewald reaction. This method allows obtaining the expected compounds in a shorter time and with better yields and purities than the classical procedures.

Key words

Gewald reaction - 5-substituted-2-aminothiophenes - microwave - arylacetaldehydes

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