Das Restless-legs-Syndrom (RLS) – Erfahrungsbericht mit einem Vitex agnus-castus (VAC)-Extrakt

Zusammenfassung

Ethanolische Extrakte der Früchte von Vitex agnus-castus (VAC) wirken als gemischter Dopamin-D₂/D₃-Rezeptoragonist. Das RLS wird therapiert mit Dopaminagonisten. Ein erster Therapieversuch mit einem standardisierten VAC-Extrakt, d.h. mit einem pflanzlichen Dopaminagonisten, an einer kleinen Patientenzahl (n = 12) ergab vielversprechende Ergebnisse, die durch systematische Untersuchungen zu verifizieren sind.

Summary

The restless legs syndrome. First experiences with an extract from Vitex agnus-castus Ethanolic extracts from the fruits of Vitex agnus-castus (VAC) act as a mixed D₂/D₃ receptor agonist. Dopamine agonists are first line therapy for restless legs syndrome (RLS). In a small group of patients (n = 12) suffering from RLS a standardized VAC extract was tested as a dopamine agonist derived from plants for the first time. The outcome is promising and further clinical trials should be stimulated.

Schlüsselwörter

Vitex agnus-castus L. - gemischter Dopaminagonist - Restless-legs-Syndrom - Erfahrungsbericht

Key words

Vitex agnus-castus L. - mixed dopamine agonist - restless legs syndrome - clinical experience - off-label use

Literatur

• r1 Baker WL. White CM. Coleman CI. Effect of nonergot dopamine agonists on symptoms of restless legs syndrome.  Ann Fam Med. 2008;  6 253-262
• r2 Barriere G. Cazalets JR. Bioulac B. , et al. The restless legs syndrome.  Prog Neurobiol. 2005;  77 139-165
• r3 Brattström A. Meier B. Dimpfel W. CNS dopamine agonist action of the Vitex agnuscastus extract Ze 440 in freely moving, chronically instrumented animals.  Z Phytother. 2008;  29 ((Suppl. 1)) S5-S6
• r4 Brattström A. Use of Vitex agnus castus extracts for preparing a medicament. 2009 Patent Internal Application No.: PTC/EP2008/007051
• r5 Collins GT. Witkin JM. Newman AH. , et al. Dopamine agonist-induced yawning in rats: a dopamine D₃ receptor-mediated behaviour.  J Pharmacol Exp Ther. 2005;  314 310-319
• r6 Collins GT. Newman AH. Grundt P. , et al. Yawning and hyperthermia in rats: effect of dopamine D₃ and D₂ agonists and antagonists.  Psychopharmacol. 2007;  193 159-170
• r7 Daniele C. Coon JT. Pittler MH. Ernst E. Vitex agnus castus. A systematic review of adverse events.  Drug Safety. 2005;  28 319-332
• r8 Hoberg E. Orjala J. Meier B. Sticher O. Diterpenoids from the fruits of Vitex agnus-castus. .  Phytochemistry. 1999;  52 1555-1558
• r9 Hoberg E. Meier B. Sticher O. Quantitative high performance liquid chromatographic analysis of casticin in the fruits of Vitex agnus-castus. .  Pharmaceutical Biol. 2001;  39 57-61
• r10 Jarry H. Leonhardt S. Wuttke W. , et al. Agnus castus als dopaminerges Wirkprinzip in Mastodynon N.  Z Phytother. 1991;  12 77-82
• r11 Jarry H. Spengler B. Wuttke W. Christoffel V. In vitro assays for bioactivity-guided isolation of endocrine active compounds in Vitex agnus-castus. .  Maturitas. 2006;  55 S26-S36
• r12 Joyce JN. Millan MJ. Dopamine D₃ receptor agonists for protection and repair in Parkinson's disease.  Curr Opin Pharmacol. 2007;  7 100-105
• r13 van Kampen JM. Robertson HA. A possible role for dopamine D₃ receptor stimulation in the induction of neurogenesis in the adult rat substantia nigra.  Neuroscience. 2005;  136 381-386
• r14 van Kampen JM. Eckman CB. Dopamine D₃ receptor agonist delivery to a model of Parkinson's diseases restores the nigrostriatal pathway and improves locomotor behaviour.  J Neuroscience. 2006;  26 7272-7280
• r15 Kushida C. Martin M. Nikam P. , et al. Burden of restless legs syndrome on health-related quality of life.  Qual Life Res. 2007;  16 617-624
• r16 Medcalf P. Bhatia KP. Restless legs syndrome.  BMJ. 2006;  333 457-458
• r17 Meier B. Berger D. Hoberg E. , et al. Pharmacological activities of Vitex agnus-castus extracts in vitro.  Phytomedicine. 2000;  7 373-381
• r18 Millan MJ. Seguin L. Gobert A. , et al. The role of dopamine D₃ compared with D₂ receptors in the control of locomotor activity: a combined behavioural and neurochemical analysis with novel, selective antagonists in rats.  Psychopharmacology. 2004;  174 341-357
• r19 Paulus W. Dowling P. Rijsman R. , et al. Pathophysiological concepts of restless legs syndrome.  Mov Disord. 2007;  22 1451-1456
• r20 Rizzo V. Arico I. Mastroeni C. , et al. Dopamine agonists restore cortical plasticity in patients with idiopathic restless legs syndrome.  Mov Disord. 2009;  24 710-705
• r21 Satija P. Ondo W. Restless legs syndrome: Pathopysiology, diagnosis and treatment.  CNS Drugs. 2008;  22 497-518
• r22 Schellenberg R. Treatment for the premenstrual syndrome with agnus castus fruit extract: prospective, randomised, placebo controlled study.  BMJ. 2001;  322 134-137
• r23 Simmen U. Löchner C. Jordan M. et al. Multiple batch affinity of a chaste tree (Vitex agnus castus L.) extract (Ze 440) to dopamine D₃ receptors. 51st Annual Congress Medicinal Plant Research, 31.8.–4.9.2003 Kiel, Germany. Book of Abstracts: p 199
• r24 Diener HC. Putzki N. Hrsg. Leitlinien für Diagnostik und Therapie in der Neurologie. 4. Aufl. Stuttgart; Thieme 2008: 56-67

Online

http://dx.doi.org/10.1055/s-0030-1262396