Zur aktuellen Debatte über die Senkung des LDL-Cholesterins durch Ezetimib

Schlüsselwörter

LDL-Cholesterin - Ezetimib - Simvastatin - Surrogatparameter

Keywords

LDL cholesterine - Ezetimibe - Simvastatin - Surrogate parameter

Literatur

• 1 Echt D S. et al . Mortality and Morbidity in Patients Receiving Encainide, Flecainide, or Placebo – The Cardiac Arrhythmia Suppression Trial.  N Engl J Med. 1991;  324 781-8
• 2 Advance Study Group . Intensive blood glucose control and vascular outcomes in patients with type 2 diabetes.  N Engl J Med. 2008;  358 2560-72
• 3 Gerstein H C. et al . Effects of intensive glucose lowering in type 2 diabetes.  N Engl J Med. 2008;  358 2545-59
• 4 Kastelein J J. et al . Simvastatin with or without ezetimibe in familial hypercholesterolemia.  N Engl J Med. 2008;  358 1431-1443
• 5 Villines T C. et al . The ARBITER 6-HALTS Trial (Arterial Biology for the Investigation of the Treatment Effects of Reducing Cholesterol 6-HDL and LDL Treatment Strategies in Atherosclerosis).  J Am Coll Cardiol. 2010;  55 2721-2726
• 6 Berneis K. et al . Ezetimibe alone or in combination with simvastatin increases small dense low-density lipoproteins in healthy men: a randomized trial.  Europ Heart J. doi:10.1093/eurheartj/ehq181