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Zeitschrift für Orthomolekulare Medizin 2011; 9(2): 10-15
DOI: 10.1055/s-0030-1271066
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© Hippokrates Verlag in MVS Medizinverlage Stuttgart GmbH & Co. KG

DHEA-Substitution: Ist 7-Keto-DHEA die bessere Substanz?

Ein ÜberblickClaus Schulte-Uebbing
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Publication History

Publication Date:
27 June 2011 (online)

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Zusammenfassung

Das sog. DHEA-Mangelsyndrom geht nicht selten mit einem beschleunigten Alterungsprozess einher. Patienten mit konstant verminderten DHEA-Werten haben möglicherweise ein erhöhtes Risiko für kardiovaskuläre Krankheiten, Immundefizit, Infektionen, Autoimmunkrankheiten und evtl. auch für bestimmte maligne Krankheiten. Eine hochdosierte DHEA-Gabe kann zu einer Erhöhung der Sexualhormone führen, was ggf. mit einem höheren Prostata- bzw. Brustkrebsrisiko einhergehen kann. 7-Keto-(3-Acetyl-7-Oxo-)DHEA wird nicht in potenziell problematische Sexualhormone metabolisiert. Eine individuelle laborkontrollierte Low-dose 7-Keto-DHEA-Gabe kann daher bei den richtigen Indikationen sehr effektiv sein.

Schlüsselwörter

DHEA - 7-Keto-(3-Acetyl-7-Oxo-)DHEA - DHEA Deficiency Syndrome (DDS)

Literaturverzeichnis als PDF

Literatur

  • 1 Alhaj et al. Effects of DHEA administration on episodic memory, cortisol and mood in healthy young men: a double-blind, placebo-controlled study.  Psychopharmacology. 2006;  188 541-551
    CrossrefSearch in Google Scholar
  • 2 Arnlöv J, Pencina M J, Amin S et al. Endogenous sex hormones and cardiovascular disease incidence in men.  Ann Intern Med. 2006;  145 176-184
    Search in Google Scholar
  • 3 Barrett-Connor E, Khaw K T, Yen S S. A prospective study of dehydroepiandrosterone sulfate, mortality, and cardiovascular disease.  N Engl J Med. 1986;  315 1519-1524
    CrossrefSearch in Google Scholar
  • 4 Boggs W. DHEA restores oxidative balance in type II diabetes. Medscape; 2007
    Search in Google Scholar
  • 5 Bulbrook R D, Hayward J L, Spicer C C. Abnormal excretion of urinary steroids by women with early breast cancer.  Lancet. 1962;  2 1238-1240
    Search in Google Scholar
  • 6 Bulbrook R D, Hayward J L, Spicer C C. Relation between urinary androgen and corticoid excretion and subsequent breast cancer.  Lancet. 1971;  2 395-398
    Search in Google Scholar
  • 7 Chen T T et al. Prevention of obesity in Avy/a mice by dehydroepiandrosterone.  Lipids. 1977;  12 409-413
    CrossrefSearch in Google Scholar
  • 8 Cleary M P, Fisk J F. Anti-obesity effect of two different levels of dehydroepiandrosterone in lean and obese middle-aged female Zucker rats.  Int J Obes. 1986;  10 193-204
    Search in Google Scholar
  • 9 Coleman D L, Leiter E H, Applezweig N. Therapeutic effects of dehydroepiandrosterone metabolites in diabetes mutant mice (C57BL/KsJ-db/db).  Endocrinology. 1984;  115 239-243
    CrossrefSearch in Google Scholar
  • 10 Coleman D L, Leiter E H, Schweizer R W. Therapeutic effects of dehydroepiandrosterone (DHEA) in diabetic mice.  Diabetes. 1982;  31 830-833
    CrossrefSearch in Google Scholar
  • 11 Coleman D L, Schweizer R W, Leiter E H. Effect of genetic background on the therapeutic effects of dehydroepiandrosterone (DHEA) in diabetes-obesity mutants and in aged normal mice.  Diabetes. 1984;  33 26-32
    CrossrefSearch in Google Scholar
  • 12 Davidson M. Safety and pharmacokinetic study with escalating doses of 3-acetyl-7-oxo-dehydroepiandrosterone in healthy male volunteers.  Clin Invest Med. 2000;  23 300-310
    Search in Google Scholar
  • 13 De Peretti E, Forest M G. Pattern of plasma dehydroepiandrosterone sulfate levels in humans from birth to adulthood: evidence for testicular production.  J Clin Endocrinol Metab. 1978;  47 572-577
    CrossrefSearch in Google Scholar
  • 14 Fukui M, Kitagawa Y, Nakamura N et al. Serum dehydroepiandrosterone sulfate concentration and carotid atherosclerosis in men with type 2 diabetes.  Atherosclerosis. 2005;  181 339-344
    CrossrefSearch in Google Scholar
  • 15 Henderson E, Yang J Y, Schwartz A. Dehydroepiandrosterone (DHEA) and synthetic DHEA analogs are modest inhibitors of HIV-1 IIIB replication.  AIDS Res Hum Retroviruses. 1992;  8 625-631
    CrossrefSearch in Google Scholar
  • 16 Henwood S M, Weeks C E, Lardy H. An escalating dose oral gavage study of 3beta-acetoxyandrost-5-ene-7,17-dione (7-oxo-DHEA-acetate) in rhesus monkeys.  Biochem Biophys Res Commun. 1999;  254 124-126
    CrossrefSearch in Google Scholar
  • 17 Kahn C. Beyond the double helix: DNA and the quest for longevity. A thorough and highly readable “inside” account of DHEA research. New York: Times Books; 1985: 143
    Search in Google Scholar
  • 18 Kawano H, Yasue H, Kitagawa A et al. Dehydroepiandrosterone supplementation improves endothelial function and insulin sensitivity in men.  J Clin Endocrinol Metab. 2003;  88 3190-3195
    CrossrefSearch in Google Scholar
  • 19 Key T, Appleby P, Barnes I, Reeves G. Endogenous sex hormones and breast cancer in postmenopausal women: reanalysis of nine prospective studies.  J Natl Cancer Inst. 2002;  94 606-616
    CrossrefSearch in Google Scholar
  • 20 Kleine-Gunk B. Anti-Aging-Medizin – Hoffnung oder Humbug?.  Deutsches Ärzteblatt. 2007;  104 http://www.aerzteblatt.de/V4/archiv/lit.asp?id=56301%2522%2520%255Cl%2520%2522nr28 28, http://www.aerzteblatt.de/V4/archiv/lit.asp?id=56301%22%20%5Cl%20%22nr29 29
    Search in Google Scholar
  • 21 Lardy H, Kneer N, Wei Y et al. Ergosteroids. II: biologically active metabolites and synthetic derivatives of dehydroepiandrosterone.  Steroids. 1998;  63 158-165
    CrossrefSearch in Google Scholar
  • 22 Löffler G, Petrides W et al. Physiologische Chemie. 8. Aufl. Berlin: Springer; 2007
    Search in Google Scholar
  • 23 Loria M, Regelson W, Padgett D A. Immune Response Facilitation and Resistance to Virus and bacterial Infections with Dehydroepiandrosterone (DHEA). In: Kalimi M, Regelson W, eds. The biologic Role of Dehydroepiandrosterone (DHEA). New York: Walter de Gruyter; 1990: 107-130
    Search in Google Scholar
  • 24 Loria R M. Immune up-regulation and tumor apoptosis by androstene steroids.  Steroids. 2002;  67 953-966
    CrossrefSearch in Google Scholar
  • 25 Loria R M, Padgett D A. Androstenediol regulates systemic resistance against lethal infections in mice.  Ann NY Acad Sci. 1993;  3-95
    Search in Google Scholar
  • 26 Martina V, Benso A, Gigliardi V R et al. Short-term dehydroepiandrosterone treatment increases platelet cGMP production in elderly male subjects.  Clin Endocrinol (Oxf ). 2006;  64 260-264
    CrossrefSearch in Google Scholar
  • 27 Nair K S, Rizza R A, O'Brien P et al. DHEA in elderly women and DHEA or testosterone in elderly men.  N Engl J Med. 2006;  355 1647-1659
    CrossrefSearch in Google Scholar
  • 28 Nyce J W, Magee P N, Hard G C, Schwartz A G. Inhibition of 1,2-dimethylhydrazine-induced colon tumorigenesis in Balb/c mice by dehydroepiandrosterone.  Carcinogenesis. 1984;  5 57-62
    CrossrefSearch in Google Scholar
  • 29 Orentreich N, Brind J L, Rizer R L, Vogelman J H. Age changes and sex differences in serum dehydroepiandrosterone sulfate concentrations throughout adulthood.  J Clin Endocrinol Metab. 1984;  59 551-555
    CrossrefSearch in Google Scholar
  • 30 Pashko L L, Schwartz A G. Effect of food restriction, dehydroepiandrosterone, or obesity on the binding of 3H-7,12-dimethylbenz(alpha)anthracene to mouse skin DNA.  J Gerontology. 1983;  38 8-12
    Search in Google Scholar
  • 31 Anonym. DHEA: the last elixir.  Prescrire International. 2002;  11 118-123
    Search in Google Scholar
  • 32 Schmidt P J, Daly R C, Bloch M et al. Dehydroepiandrosterone monotherapy in midlife-onset major and minor depression.  Arch Gen Psychiatry. 2005;  62 154-162
    CrossrefSearch in Google Scholar
  • 33 Schulz S, Klann R C, Schönfeld S, Nayce J W. Mechanisms of cell growth inhibition and cell cycle arrest in human colonic adenocarcinoma cells by dehydroepiandrosterone: role of isoprenoid biosynthesis.  Cancer Res. 1992;  52 1372-1376
    Search in Google Scholar
  • 34 Schulte-Uebbing C. DHEA Substitution. In: Umweltbedingte Frauenkrankheiten. Lehrbuch [Environmentally-induced Gynaecological Illnesses], textbook for gynaecologists, naturopaths and environmental physicians. Stuttgart: Sonntag; 1994
    Search in Google Scholar
  • 35 Schulte-Uebbing C, Schlett S. Vitamin D in der gynäkologischen Praxis, Ergebnisse einer Anwendungsbeobachtung.  CO MED. 2010;  3 3-10
    Search in Google Scholar
  • 36 Schulte-Uebbing C. Ursachen von Endometriose: Schlussfolgerungen aus Praxiserfahrung und Nachuntersuchung.  ZKM. 2010;  2 18-21
    Search in Google Scholar
  • 37 Schulte-Uebbing C, Schlett S. Kolpitis und Co. – vaginale Vitamin-D-Applikation hilft.  Gyn Geb. 2010;  3 2-3
    Search in Google Scholar
  • 38 Schulte-Uebbing C. Mammovision – ein komplementäres Mamma-Diagnostik-Verfahren.  ZÄN (zaenmagazin). 2010;  2 13-19
    Search in Google Scholar
  • 39 Schulte-Uebbing C. Infrarot-Thermographie, endokrinologische Einflussfaktoren.  EHK. 2010;  59 226-232
    Thieme ConnectSearch in Google Scholar
  • 40 Schulte-Uebbing C. Toxikologische, infektiologische und immunologische Aspekte des Mammakarzinoms. Klinikum Rechts der Isar der Technischen Universität München; 2009: 4-9
    Search in Google Scholar
  • 41 Schulte-Uebbing C. 9. Konferenz der GSAAM. München; 2009: 4-9
    Search in Google Scholar
  • 42 Schulte-Uebbing C. Applied anti aging medicine. 8th International Congress Plastic Surgery, Bukarest, 5/2008. Schulte-Uebbing C. Anti aging and preventive medicine aspects. Int. Health Academy, Meran, 5/2008
  • 43 Schulte-Uebbing C. Umweltmedizinische Aspekte des Anti-Aging. Umweltmedizinische Aspekte des Anti-Aging, Vorträge und Workshops, Internationale Ärztekongresse „Anti-Aging“. Universität Heidelberg, Berlin, Wien 2001–2003
    Search in Google Scholar
  • 44 Zahn V, Schulte-Uebbing C. Lehrbuch der Umweltmedizin. (Erstes deutschsprachiges Lehrbuch für Umweltmediziner, 560 Seiten.) München: Umgewe; 1990
    Search in Google Scholar
  • 45 Schulte-Uebbing C. Steroids as inhibitors of human placental Glutathione-S-Transferase by steroids. Aachen; Vortrag “Placenta-Kongreß” 1986
    Search in Google Scholar
  • 46 Schulte-Uebbing C. Inhibition of human placental glutathione-S transferase by steroids.  Placenta. 1987;  1
    Search in Google Scholar
  • 47 Schulte-Uebbing C, Dibbelt L, Kuss E. Human placental glutathione-S transferase: interactions with steroids.  Biol Chem Hoppe-Seyler. 1988;  369 23-28
    Search in Google Scholar
  • 48 Schwartz A G. Inhibition of spontaneous breast cancer formation in female C3H(Avy/a) mice by long-term treatment with dehydroepiandrosterone.  Cancer Res. 1979;  39 1129-1132
    Search in Google Scholar
  • 49 Schwartz A G, Hard G C, Pashko L L et al. Dehydroepiandrosterone: an antiobesity and anti-carcinogenic agent.  Nutr Cancer. 1981;  3 46-53
    CrossrefSearch in Google Scholar
  • 50 Schwartz A G, Nyce J W, Tannen R H. Inhibition of tumorigenesis and autoimmune development in mice by dehydroepiandrosterone.  Mod Aging Res. 1984;  6 177-184
    Search in Google Scholar
  • 51 Schwartz A G, Fairman D K, Pashko L L. The biological Significance of Dehydroepiandrosterone. In: Kalimi M, Regelson W, eds. The biologic Role of Dehydroepiandrosterone (DHEA). New York: Walter de Gruyter; 1990
    Search in Google Scholar
  • 52 Tworoger S S, Missmer S A, Eliassen A H et al. The association of plasma DHEA and DHEA sulfate with breast cancer risk in predominantly premenopausal women.  Cancer Epidemiol Biomarkers Prev. 2006;  15 967-971
    CrossrefSearch in Google Scholar
  • 53 Wallace M B, Lim J, Cutler A, Bucci L. Effects of dehydroepiandrosterone vs. androstenedione supplementation in men.  Med Sci Sports Exerc. 1999;  31 1788-1792
    Search in Google Scholar
  • 54 Wolkowitz O M, Kramer J H, Reus V I et al. DHEA treatment of Alzheimer's disease: a randomized, double-blind, placebo-controlled study.  Neurology. 2003;  60 1071-1076
    CrossrefSearch in Google Scholar
  • 55 Wolkowitz O M, Reus V I, Keebler A et al. Double-blind treatment of major depression with dehydroepiandrosterone.  Am J Psych. 1999;  156 646-649
    Search in Google Scholar
  • 56 Yen T T, Allan J A, Pearson D V, Acton J M, Greenberg M M. Prevention of obesity in Avy/a mice by dehydroepiandrosterone.  Lipids. 1977;  12 409-413
    CrossrefSearch in Google Scholar
  • 57 Yang N C, Jeng K C, Ho W M, Hu M. ATP depletion is an important factor in DHEA-induced growth inhibition and apoptosis in BV-2 cells.  Life Sci. 2002;  70 1979-1988
    CrossrefSearch in Google Scholar
  • 58 Young E A, Haskett R F, Grunhaus L et al. Increased evening activation of the hypothalamic-pituitary-adrenal axis in depressed patients.  Arch Gen Psychiatry. 1994;  51 701-707
    CrossrefSearch in Google Scholar
  • 59 Enomoto M, Adachi H, Fukami A et al. Serum dehydroepiandrosterone sulfate levels predict longevity in men: 27-year follow-up study in a community-based cohort (Tanushimaru Study).  J Am Geriatr Soc. 2008;  56 994-998
    CrossrefSearch in Google Scholar
  • 60 Hayashi T, Esaki T, Muto E et al. Dehydroepiandrosterone retards atherosclerosis formation through its conversion to estrogen, the possible role of nitric oxide.  Arterioscler Thromb Vasc Biol. 2000;  20 782
    CrossrefSearch in Google Scholar
  • 61 Loria R M, Padgett D A, Huynh P N. Regulation of the immune response by dehydroepiandrosterone and its metabolite.  J Endocrinol. 1996;  150 S209-S220
    Search in Google Scholar
  • 62 Merril C R, Harrington M G. Plasma dehydroepiandrosterone levels in HIV infection (letter).  JAMA. 1989;  261 1149
    CrossrefSearch in Google Scholar
  • 63 Mulder J W, Frissen P H, Krijnen P et al. Serum dehydroepiandrosterone (DHEA) levels in asymptomatic HIV-1 infected subjects.  J Infect Dis. 1992;  165 413-418
    CrossrefSearch in Google Scholar
  • 64 Panjari M, Davis S R. DHEA therapy for women: effect on sexual function and wellbeing.  Hum Reprod Update May 1,. 2007;  13 239-248
    Search in Google Scholar
  • 65 Piketty C, Jayle D et al. DHEA might lower “good cholesterol”.  Proc Natl Acad Sci USA. 2001;  98 8145-8150
    CrossrefSearch in Google Scholar
  • 66 Rosack J et al. Disappointing data confound claims for DHEA effectiveness.  Psychiatric News. 2003;  38 38
    Search in Google Scholar
  • 67 Yen S S C, Morales A J, Khorram O. Replacement of DHEA in aging men and women: potential remedial effects.  Am J Med Sci. 1996;  311 205-210
    CrossrefSearch in Google Scholar

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Prof. Dr. med. Claus Schulte-Uebbing

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80333 München

Email: dr-schulte-uebbing@t-online.de

Prof. Dr. med. Claus Schulte-Uebbing ist Frauenarzt mit den Spezialisierungen Onkologie, Immunologie, Endokrinologie, Umweltmedizin und leitet das Umweltmedizinische Therapiezentrum am Dom in München. Zudem arbeitet er als umweltmedizinischer Gutachter und ist Autor zahlreicher medizinischer Fach- und Lehrbücher.