RSS-Feed abonnieren
DOI: 10.1055/s-0031-1273428
© Georg Thieme Verlag KG Stuttgart · New York
Versorgungswege von erstmanifesten psychotischen Patienten – eine Übersicht internationaler Studien
Pathways-to-Care for First-Episode Psychotic Patients – An Overview of International StudiesPublikationsverlauf
Publikationsdatum:
07. Juli 2011 (online)

Zusammenfassung
Eine längere Dauer der unbehandelten Psychose (DUP) und der unbehandelten Erkrankung (DUI) ist mit einem negativen Krankheitsverlauf von Psychosen assoziiert. Daher gibt es zunehmend Bemühungen, die DUP zu verkürzen und Betroffene frühzeitig einer adäquaten Therapie zuzuführen. Um frühe Hindernisse bei der Hilfesuche abzubauen, müssen diese zunächst identifiziert werden. Daher wird eine Übersicht initialer Hilfesuchkontakte und über Prädiktoren von Behandlungsverzögerungen bei psychotischen Erstmanifestationen gegeben. Die DUP weist über alle 25 identifizierten Studien eine ungünstige Länge von gut einem Jahr auf, wobei es im Vorfeld im Mittel zu drei Kontakten vor der Behandlungsaufnahme kam. Da Hindernisse in den Versorgungswegen auf allen relevanten Ebenen (Patient, Umwelt und Versorgungssystem) identifiziert wurden, liegen Optimierungsmöglichkeiten in der Vernetzung der Anlaufstellen und kontinuierlicher Aufklärungsarbeit der Bevölkerung und medizinisch-psychologischer Fachkräften.
Abstract
A longer duration of untreated psychosis (DUP) as well as of untreated illness (DUI) was found to be associated with a negative course of psychosis. Thus, increasing efforts are made to reduce the DUP and provide adequate treatment as early as possible. But, in order to overcome obstacles to early help-seeking, these have to be identified first. Thus, an overview on initial help-seeking behaviour and predictors of DUP is given. Across 25 identified studies, the DUP, at about one year on average, is still unfavourably long and includes on average of three help-seeking contacts prior to the initiation of adequate treatment. Since negative factors in pathways-to-care involve features on all relevant levels (patient, social environment and health-care system), an optimisation of pathways-to-care will require the integration of services and continuous awareness programmes targeting the general population and mental health-care professionals.
Schlüsselwörter
Psychose - Prodrom - Versorgungswege - Dauer der unbehandelten Psychose (DUP) - Behandlungsverzögerung - Hilfesuche
Keywords
psychosis - prodrome - pathways-to-care - duration of untreated psychosis (DUP) - treatment delay - help-seeking
Literatur
- 1 WHO, World Health Organiation .Prevention of Mental Disorder. Effective interventions an policy options. Genf: WHO; 2004
MissingFormLabel
- 2
Marshall M, Lewis S, Lockwood A et al.
Association between duration of untreated psychosis and outcome in cohorts of first-episode
patients: a systemativ review.
Arch Gen Psychiatry.
2005;
62
975-983
MissingFormLabel
- 3
Schimmelmann B G, Huber C G, Lampert M et al.
Impact of duration of untreated psychosis on pre-treatment, baseline, and outcome
characteristics in an epidemiological first-episode psychosis cohort.
J Psychiatr Res.
2008;
42
982-990
MissingFormLabel
- 4
Singh S P, Grange T.
Measuring pathways to care in first-episode psychosis: A systematic review.
Schizophr Res.
2006;
81
75-82
MissingFormLabel
- 5
Wang P S, Angermeyer M, Borges G et al.
Delay and failure in treatment seeking after first onset of mental disorders in the
World Health Organizations World Mental Health Survey Initiative.
World Psychiatry.
2007;
6
177-118
MissingFormLabel
- 6
Rogler L H, Cortes D E.
Help-Seeking pathways: a unifying concept in mental health care.
Am J Psychiatry.
1993;
150
554-561
MissingFormLabel
- 7
Lindert J, Schouler-Ocak M, Heinz A et al.
Mental health, health care utilisation of migrants in Europe.
Eur Psychiatry.
2008;
23
14-20
MissingFormLabel
- 8
Eisenberg D, Golberstein E, Gollust S E.
Help-Seeking and Access to Mental Health Care in a University Student Population.
Med Care.
2007;
45
594-601
MissingFormLabel
- 9
Compton M T, Esterberg M L, Druss B G et al.
A descriptive study of pathways to care among hospitalized urban African American
first-episode schizophrenia-spectrum patients.
Soc Psychiatry Psychiatr Epidemiol.
2006;
41
566-573
MissingFormLabel
- 10
Zachrisson H D, Rödje K, Mykletun A.
Utilization of health services in relation to mental health problems in adolescents:
A population based survey.
BMC Public Health.
2006;
6
34
MissingFormLabel
- 11
Amaddeo F, Zambello F, Tansanella M et al.
Accessibility and pathways to psychiatric care in a community-based mental health
system.
Soc Psychiatry Psychiat Epidemiol.
2001;
36
500-507
MissingFormLabel
- 12
Andrade L H, Vianna M C, Tofoli L FF et al.
Influence of psychiatric morbidity and sociodemografic determinants on use of service
in a catchment area in the city of Sao Paolo, Brazil.
Soc Psychiatry Psychiatr Epidemiol.
2008;
43
45-51
MissingFormLabel
- 13
Gater R, Goldberg D.
Pathways to Psychiatric Care in South Manchester.
Br J Psychiatry.
1991;
159
90-96
MissingFormLabel
- 14
Gater R, Jordanova V, Maric N et al.
Pathways to psychiatric care in Eastern Europe.
Br J Psychiatry.
2005;
186
529-535
MissingFormLabel
- 15
McMiller W P, Weisz J R.
Help-Seeking Preceding Mental Health Clinic Intake among African-American, Latino
and Caucasian Youths.
J Am Acad Child Adolesc Psychiatry.
1996;
35
8
MissingFormLabel
- 16
Rickwood D J, Deane F P, Wilson C J.
When and how do young people seek professional help for mental health problems?.
MJA.
2007;
187
35-39
MissingFormLabel
- 17
Steel Z, McDonald R, Silove D et al.
Pathways to the first contact with specialist mental health care.
Aust N Z J Psychiatry.
2006;
40
347-354
MissingFormLabel
- 18
Addington J, Mastrigt van S, Hutchinson J et al.
Pathways to care: help seeking behaviour in first episode psychosis.
Acta Psychiatr Scand.
2002;
106
358-364
MissingFormLabel
- 19
Archie S, Akthar-Danesch N, Norman R et al.
Ethnic Diversity and Pathways to Care for a First Episode of Psychosis in Ontario.
Schizophr Bull.
2008;
DOI: 10.1093 /schbul/sbn137
MissingFormLabel
- 20
Bechard-Evans L, Schmitz N, Abadi S et al.
Determinants of help-seeking and system related components of delay in the treatment
of first-episode psychosis.
Schizophr Res.
2007;
96
206-214
MissingFormLabel
- 21
Boydell K M, Gladstone B M, Volpe T.
Understanding Help Seeking Delay in the prodrom to First episode Psychosis: A Secondary
Analysis of the Perspectives of Young People.
Psychiatr Rehabil J.
2006;
30
54-60
MissingFormLabel
- 22
Burnett R, Mallet R, Bhugra D et al.
The first contact of patients with schizophrenia with psychiatric services: social
factors and pathways to care in a multi-ethnic population.
Psychol Med.
1999;
29
475-483
MissingFormLabel
- 23
Chong S A, Mythily S, Verma S.
Reducing the duration of untreated psychosis and changing help-seeking behaviour in
Singapore.
Soc Psychiatry Psychiatr Epidemiol.
2005;
40
619-621
MissingFormLabel
- 24
Chong S A, Mythily S, Lum A et al.
Determinations of duration of untreated psychosis and the pathway to care in Singapore.
Int Journal Soc Psychiatry.
2005;
51
55-62
MissingFormLabel
- 25
Cole E, Leavy G, King M et al.
Pathways to Care for Patients with a First Episode of Psychosis. A Comparison of Ethnic
Groups.
Br J Psychiatry.
1995;
167
770-776
MissingFormLabel
- 26
Cougnard A, Kalmi E, Desage A et al.
Pathways to care of first-admitted subjects with psychosis in South-Western-France.
Psychol Med.
2004;
34
267-276
MissingFormLabel
- 27
Etheridge K, Yarrow L, Peet M.
Pathways to care in first-episode psychosis.
J Psychiatr Ment Health Nurs.
2004;
11
125-128
MissingFormLabel
- 28
Fuchs J, Steinert T.
Inanspruchnahme professioneller Hilfe, Einweisungswege und Dauer der unbehandelten
Psychose bei erstmals stationär aufgenommenen Patienten.
Fortschr Neurol Psychiatr.
2002;
70
40-45
MissingFormLabel
- 29
Fuchs J, Steinert T.
Patients with first episode of schizophrenia spectrum psychosis and their pathways
to psychiatric hospital care in South Germany.
Soc Psychiatry Psychiatr Epidemiol.
2004;
39
375-380
MissingFormLabel
- 30
Jablensky A, Sartorius N, Ernberg G et al.
Schizophrenia: manifestations, incidence and course in different cultures. A World
Health Organisation Ten-Country Study.
Psychol Med Monogr Suppl.
1992;
22
1092
MissingFormLabel
- 31
Joa I, Johannsessen J O, Auestad B et al.
The key to reducing duration of untreated first psychosis: information campaigns.
Schizophr Bull.
2008;
34
472-466
MissingFormLabel
- 32
Johnstone E C, Crow T J, Johnson A L et al.
The Northwick Park Study of first episodes of schizophrenia. I. Presentation of the
illness and problems relating to admission.
Br J Psychiatry.
1986;
148
115-120
MissingFormLabel
- 33
Johnstone E C, MacMillian J, Crow T et al.
The Northwick Park first episodes of schizophrenia. III. Short-term outcome in trial
entrants and trial eligible patients.
Br J Psychiatry.
1986;
148
128-133
MissingFormLabel
- 34
Köhn D, Pukrop R, Niedersteberg A et al.
Wege in die Behandlung: Hilfesuchverhalten schizophrener Ersterkrankter.
Fortschr Neurol Psychiatr.
2004;
72
1-8
MissingFormLabel
- 35
Larsen T K, Johannessen J O, Opjordsmoen S.
First episode schizophrenia with long duration of untreated psychosis.
Br J Psychiatry.
1998;
172 (Suppl 33)
45-52
MissingFormLabel
- 36
Lincoln C, Harrigan S, McGorry P D.
Understanding the topografy of the early psychosis pathway.
Br J Psychiatry.
1998;
172 (Suppl 33)
21-25
MissingFormLabel
- 37
Morgan C, Mallett R, Hutchinson G et al.
Pathways to care and ethnicity. 1: Sample characteristics and compulsory admission.
Br J Psychiatry.
2005;
186
281-289
MissingFormLabel
- 38
Morgan C, Mallett R, Hutchinson G et al.
Pathways to care and ethnicity. 2: Source of referral and help-seeking.
Br J Psychiatry.
2005;
186
290-296
MissingFormLabel
- 39
Naqvi H A, Hussain S, Zaman M et al.
Duration of untreated Psychosis form Karachi, Pakistan.
Plos One.
2009;
4
e7409
MissingFormLabel
- 40
Norman R M, Malla A K, Verdi M B et al.
Understanding delay in treatment for first-episode psychosis.
Psychol Med.
2004;
34
255-266
MissingFormLabel
- 41
Norman R M, Malla A K, Manchanda R.
Delay in treatment for psychosis.
Soc Psychiatry Psychiatr Epidemiol.
2007;
42
507-512
MissingFormLabel
- 42
O’Callaghan E, Turner N, Renwick L et al.
First episode psychosis and the trail to secondary care: help-seeking and health-system
delays.
Soc Psychiatry Psychiatr Epidemiol.
2010;
45
381-391
MissingFormLabel
- 43
Pek E, Mythily S, Chong S A.
Clinical and Social Correlates of Duration of Untreated Psychosis in First-episode
Psychosis Patients.
Ann Acad Med Singapore.
2006;
35
24-26
MissingFormLabel
- 44
Platz C, Umbricht D S, Cattapan-Ludewig K et al.
Help-seeking pathways in early psychosis.
Soc Psychiatry Psychiatr Epidemiol.
2006;
41
967-974
MissingFormLabel
- 45
Skeate A, Jackson C, Birchwood M et al.
Duration of untreated psychosis and pathways to care in first-episode psychosis.
Br J Psychiatry.
2002;
181 (Suppl 43)
73-77
MissingFormLabel
- 46
Turner M, Smith-Hamel C, Mulder R.
Pathways to care in a New Zeeland first-episode of psychosis cohort.
Aust N Z J Psychiatry.
2006;
40
421-428
MissingFormLabel
- 47
Temmingh H S, Oosthuizen P P.
Pathways to care and treatment delays in first and multi episodes psychosis.
Soc Psychiatry Psychiatr Epidemiol.
2008;
43
727-735
MissingFormLabel
- 48
Wong D FK.
Uncovering sociocultural factors influencing the pathway to care of Chinese caregivers
with relatives suffering from early psychosis in Hong Kong.
Cult Med Psychiatry.
2007;
31
51-71
MissingFormLabel
- 49
Yamazawa R, Mizuno M, Nemoto T et al.
Duration of untreated psychosis and pathways to psychiatric services in first-episode
schizophrenia.
Psychiatry Clin Neurosci.
2004;
58
76-81
MissingFormLabel
- 50
Cremer H, Pestieau P.
Social insurance competition between Bismarck and Beveridge.
Journal of Urban Economics.
2003;
54
181-196
MissingFormLabel
- 51
Johannessen J O, Larsen T K, Joa I et al.
Pathways to care for first-episode psychosis in early detection healthcare sector.
Br J Psychiatry.
2005;
187 (Suppl 48)
24-28
MissingFormLabel
- 52
Häfner H, Riecher A, Maurer K et al.
Ein Instrument zur retrospektiven Einschätzung des Erkrankungsbeginns bei Schizophrenie
(IRAOS) – Entwicklung und erste Ergebnisse.
Zt Klin Psychol.
1990;
19
230-255
MissingFormLabel
- 53
Köhn D, Niedersteberg A, Wieneke A et al.
Frühverlauf schizophrener Ersterkrankungen mit langer Dauer der unbehandelten Erkrankung.
Fortschr Neurol Psychiatr.
2004;
72
88-92
MissingFormLabel
- 54
Kiliç C, Rezaki M, Ustun T B et al.
Pathways to psychiatric care in Ankara.
Social Psychiatry Psychiatr Epidemiol.
1994;
29
131-136
MissingFormLabel
- 55
Chen E YH, Dunn E LW, Miao M YK et al.
The impact of family experience on the duration of untreated psychosis (DUP) in Hong
Kong.
Soc Psychiatry Psychiatr Epidemiol.
2005;
40
350-356
MissingFormLabel
- 56
Kessler R C, Berglund P A, Bruce M L et al.
The Prevalence and Correlates of Untreated Serious Mental Illness.
Health Serv Res.
2001;
36(6 Pt 1)
1009-1017
MissingFormLabel
- 57
Jorm A F, Christensen H, Griffith K M.
The public’s ability to recognize mental disorders and their beliefs about treatment:
changes in Australia over 8 years.
Aust N Z J Psychiatry.
2006;
40
36-41
MissingFormLabel
- 58
Angel R, Throits P.
The impact of culture on the cognitive structure of illness.
Cult Med Psychiatry.
1987;
11
465-494
MissingFormLabel
- 59 Fink P J, Tasman A. Stigma and Mental Illness. 1. Aufl Washington DC: American Psychiatric Press; 1992
MissingFormLabel
- 60
Steele L, Dewa C, Lee K.
Socioeconomic Status and Self-Reported Barriers to Mental Health Service Use.
Can J Psychiatry.
2007;
52
201-206
MissingFormLabel
- 61
Lincoln C V, McGorry P D.
Who cares? Pathways to care in early psychosis.
Psychiatr Serv.
1995;
46
1166-1171
MissingFormLabel
- 62
Simon A E, Lauber C, Ludewig K et al.
Swiss Early Psychosis Project. General practitioners and schizophrenia: results from
a Swiss survey.
Br J Psychiatry.
2005;
187
274-281
MissingFormLabel
- 63
Simon A E, Roth B, Zmilacher S et al.
Developing services for the early detection of psychosis: a critical consideration
of the current state of the art.
Eur Child Adolesc Psychiatry.
2007;
16
96-103
MissingFormLabel
- 64
Strakowski S M, Tohen M, Stoll A L et al.
Comorbidity in Psychosis at First Hospitalization.
Am J Psychiatry.
1993;
150
752-757
MissingFormLabel
- 65
Strakowski S M, Keck P E, McElroy S L et al.
Chronology of comorbid and principal syndromes in first-episode psychosis.
Compr Psychiatr.
1995;
36
106-112
MissingFormLabel
- 66 Becker I. Komorbidität im Frühverlauf von Psychosen. Dissertation an der Medizinischen Fakultät der Universität zu Köln; 2007
MissingFormLabel
- 67
Klosterkötter J, Hellmich M, Schultze-Lutter F.
Ist die Diagnose schizophrener Störungen schon in der initialen Prodromalphase vor
der psychotischen Erstmanifestation möglich?.
Fortschr Neurol Psychiatr.
2000;
68 (Sonderheft 1)
13-21
MissingFormLabel
- 68
Rosen J L, Miller T J, D’Andrea J T et al.
Comorbid diagnoses in patients meeting criteria for the schizophrenia prodrome.
Schizophr Res.
2006;
85
124-31
MissingFormLabel
- 69
Salokangas R KR, Luutonen S, Nieminen M et al.
Vulnerability to psychosis increases the risk of depression. Results from the RADEP
study.
Nord J Psychiatry.
2007;
61
393-402
MissingFormLabel
- 70
Svirskis T, Korkeila J, Heinimaa M et al.
Axis-I disorders and vulnerability to psychosis.
Schizophr Res.
2005;
75
439-446
MissingFormLabel
- 71
Schultze-Lutter F, Ruhrmann S, Picker H et al.
The distinction between depressive and early psychotic symptoms.
Br J Psychiatry.
2007;
191 (Suppl 51)
31-37
MissingFormLabel
- 72
Helgason L.
Twenty years’ follow-up of first psychiatric presentation for schizophrenia: what
could have been prevented?.
Acta Psychiatr Scand.
1990;
81
231-235
MissingFormLabel
- 73
McGorry P D, Edwards J, Mihalopoulos C et al.
EPPIC: an evolving system of early detection and optimal management.
Schizophr Bull.
1996;
22
305-326
MissingFormLabel
- 74
Klosterkötter J, Schultze-Lutter F.
Gibt es eine Primärprävention schizophrener Psychosen?.
Fortschr Neurol Psychiat.
2001;
69 (Sonderheft 2)
S104-S112
MissingFormLabel
Dr. Frauke Schultze-Lutter
Kinder- und Jugendpsychiatrie, Forschungsabteilung, Universitäre Psychiatrische Dienste
(UPD)
Bolligenstr. 111
3000 Bern 60
Schweiz
eMail: frauke.schultze-lutter@kjp.unibe.ch