Histidine-Rich Glycoprotein: A Possible Modulator of Coagulation and Fibrinolysis

Sadao Wakabayashi; Takehiko Koide

doi:10.1055/s-0031-1276588

Seminars in Thrombosis and Hemostasis, Table of Contents

Semin Thromb Hemost 2011; 37(4): 389-394
DOI: 10.1055/s-0031-1276588

Histidine-Rich Glycoprotein: A Possible Modulator of Coagulation and Fibrinolysis

Sadao Wakabayashi¹ , Takehiko Koide¹

¹Department of Life Science, Graduate School of Life Science, University of Hyogo, Harima Science Garden City, Hyogo, Japan

Abstract

ABSTRACT

Histidine-rich glycoprotein (HRG) is one of the major plasma proteins and thought to function in blood coagulation, fibrinolysis, and innate immune systems. The amino acid sequence of HRG revealed a multidomain structure consisting of cystatin-like domains 1 and 2, a Pro-rich domain 1, a His-rich domain, a Pro-rich domain 2, and a C-terminal domain. Broad ligand-binding properties of HRG are involved in the multivalent functions of HRG. Among various functions of HRG, its interactions with heparin/heparan sulfate, fibrinogen, and plasminogen are thought to be intimately related to its roles in the coagulation and fibrinolytic systems. Recent studies on these topics are mainly reviewed in this article. The newly disclosed abilities of HRG in angiogenesis, its antibacterial effect, its activation of T-cell lines in cooperation with Concanavalin A, and the identification of a putative receptor for HRG on T cell lines are also described.

KEYWORDS

Histidine-rich glycoprotein - HRG - coagulation - fibrinolysis

Full Text

References

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Takehiko KoideD.Sc.

Professor, Department of Life Science, Graduate School of Life Science, University of Hyogo

Harima Science Garden City, Hyogo 678-1297, Japan

Email: koide@sci.u-hyogo.ac.jp