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Semin Thromb Hemost 2011; 37(4): 395-407
DOI: 10.1055/s-0031-1276589
© Thieme Medical Publishers

Forty Years Later and the Role of Plasminogen Activator Inhibitor Type 2/SERPINB2 Is Still an Enigma

Jodi A. Lee1 , Blake J. Cochran1 , Sergei Lobov1 , Marie Ranson1
  • 1School of Biological Sciences, University of Wollongong, Wollongong NSW, Australia
Further Information

Publication History

Publication Date:
30 July 2011 (online)

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ABSTRACT

Plasminogen activator inhibitor (PAI)-2 expression is acutely upregulated in pregnancy, inflammation, infection, and other pathophysiological conditions. Circumstances that prevent PAI-2 upregulation are associated with chronic pathology. Altogether this strongly suggests that PAI-2 is one of the many proteins that maintain homeostasis during damage or stress. However, several functions ranging from a classical serpin to various intracellular roles have been ascribed to PAI-2 and, because none of these have been definitively proven in vivo, to this day its precise role or roles remains an enigma. This review readdresses the evidence supporting a role for PAI-2 in fibrinolysis and proteolysis within extracellular environments and includes a review of the many potential intracellular functions attributed to PAI-2.

KEYWORDS

PAI-2 - SERPINB2 - proteolysis - fibrinolysis - extracellular - intracellular

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Marie RansonPh.D. 

School of Biological Sciences, University of Wollongong, Northfields Avenue

Wollongong NSW 2522, Australia

Email: mranson@uow.edu.au