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Klin Padiatr 2011; 223(7): 434-435
DOI: 10.1055/s-0031-1277216
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Severe Rhabdomyolysis Caused by Valproic Acid in a Neonate with Seizures and Chromosomal Abnormalities

Schwere Rhabdomyolyse nach Valproat-Therapie bei einem Neugeborenen mit Krampfanfällen und ChromosomenanomalieS. Meyer1 , 2 , T. Martin3 , G. Löffler1 , L. Gortner1
  • 1Department of Pediatric and Neonatal Intensive Care, University Hospital of Saarland, Homburg, Germany
  • 2Department of Neuropediatrics, University Hospital of Saarland, Homburg, Germany
  • 3Medical Practice of Human Genetics, Homburg, Germany
Further Information

Publication History

Publication Date:
25 May 2011 (online)

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Key words

valproic acid - rhabdomyolysis - neonate - chromosomal abnormalities

Schlüsselwörter

Valproinsäure - Rhabdomyolyse - Neugeborenes - chromosomale Veränderungen

References

  • 1 Kottlors M, Jaksch M, Ketelsen UP. et al . Valproic acid triggers acute rhabdomyolysis in a patient with carnitine palmitoyltransferase type II deficiency.  Neuromusc Disord. 2001;  11 757-759
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  • 2 Lheureux PE, Hantson P. Carnitine in the treatment of valproic acid-induced toxicity.  Clin Toxicol. 2009;  47 101-111
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  • 3 Meyer S, Kuhlmann MK, Peters FT. et al . Severe valproic acid intoxication is associated with atrial tachycardia: secondary detoxicaton by hemoperfusion.  Klin Padiatr. 2005;  217 82-85
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  • 4 Naranjo CA, Busto U, Sellers EM. et al . A method for estimating the probability of adverse drug reactions.  Clin Pharmacol Ther. 1981;  30 239-245
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  • 5 Prandstetter C, Tamesberger M, Wagner. et al . Medical prescriptions to premature and newborn infants in an Austrian neonatal intensive care unit.  Klin Padiatr. 2009;  221 312-317
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  • 6 Roth B. Off-label and unlicenced use of drugs in neonatal intensive care.  Klin Padiatr. 2009;  22 275-277
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Correspondence

PD Dr. Sascha MeyerMD 

Department of Pediatric and

Neonatal Intensive Care

University Hospital of Saarland

Building 9

Kirrbergerstraße

66421 Homburg

Germany

Phone: +49/6841/162 83 74

Fax: +49/6841/162 83 63

Email: sascha.meyer@uniklinikum-saarland.de