pferde spiegel, Table of Contents pferde spiegel 2011; 14(3): 98-104DOI: 10.1055/s-0031-1280186 fachspiegel © Enke Verlag in MVS Medizinverlage Stuttgart GmbH & Co. KG Aktueller Stand der Diagnostik und Therapie des Equinen Cushing Syndroms Current diagnosis and therapy of the equine Cushing SyndromeJasmin-Isabelle Michutta, Robert Schmitz, Heidrun Gehlen Recommend Article Abstract Buy Article All articles of this category Summary Equine pituitary pars intermedia dysfunction (PPID) is a common endocrinopathy of aged horses, caused by an adenoma in the pars intermedia of the pituitary gland. The dexamethasone suppression test has been considered as gold standard test for the diagnosis of PPID, but determination of resting ACTH concentrations was besides other diagnostic tests a good alternative. Oral pergolide is used in treatment of PPID and has been shown to be beneficial to reduce the clinical signs. Key words Equines Cushing Syndrom - Pituitary Pars Intermedia Dysfunction - Hypophysenadenom - Pergolidmesilat - Dexamethason-Suppressionstest Full Text References Literatur 1 Couetil L, Paradis M R, Knoll J. Plasma adrenocorticotropin concentration in healthy horses and in horses with clinical signs of hyperadrenocorticism. J Vet Intern Med. 1996; 10 1-6 2 Donaldson M T, LaMonte B H, Morresey P. Treatment with pergolide or cyproheptadine of pituitary pars intermedia dysfunction (equine Cushing's disease). J Vet Intern Med. 2002; 16 742-746 3 Dybdal N O, Hargreaves K M, Madigan J E. Diagnostic testing for pituitary pars intermedia dysfunction in horses. J Am Vet Med Assoc. 1994; 204 627-632 4 Frank N, Andrews F M, Sommardahl C S. Evaluation of the combined dexamethasone suppression/thyrotropin-releasing hormone stimulation test for detection of pars intermedia pituitary adenomas in horses. J Vet Intern Med. 2006; 20 987-993 5 Haritou S J, Zylstra R, Ralli C. Seasonal changes in circadian peripheral plasma concentrations of melatonin, serotonin, dopamine and cortisol in aged horses with Cushing's disease under natural photoperiod. J Neuroendocrinol. 2008; 20 988-996 6 McFarlane D. Endocrine and Metabolic Diseases. In: Smith B, ed. Large Animal Internal Medicine. St. Louis, MO: Mosby Elsevier; 2009: 1339-1344 7 Sojka J. Pituitary Pars intermedia Dysfunction. In: Robinson N, Sprayberry K, eds. Current Therapy in equine Medicine 6. St. Louis, MO: Saunders Elsevier; 2009: 732-735 8 McFarlane D, Toribio R. Pituitary Pars intermedia Dysfunction (Equine Cushing's Disease). In: Reed S, Bayly W, Sellon D, eds. Equine internal Medicine. St. Louis, MO: Saunders Elsevier; 2010: 1262-1270 9 McGowan C M, Neiger R. Efficacy of trilostane for the treatment of equine Cushing's syndrome. Equine Vet J. 2003; 35 414-418 10 McGowan C M, Frost R, Pfeiffer D U. Serum insulin concentrations in horses with equine Cushing's syndrome: response to a cortisol inhibitor and prognostic value. Equine Vet J. 2004; 36 295-298 11 Miller M A, Pardo I D, Jackson L P. Correlation of pituitary histomorphometry with adrenocorticotrophic hormone response to domperidone administration in the diagnosis of equine pituitary pars intermedia dysfunction. Vet Pathol. 2008; 45 26-38 12 Perkins G A, Lamb S, Erb H N. Plasma adrenocorticotropin (ACTH) concentrations and clinical response in horses treated for equine Cushing's disease with cyproheptadine or pergolide. Equine Vet J. 2002; 34 679-685 13 Schott H C, Graves E A, Refsal K R. Diagnosis and treatment of pituitary pars intermedia dysfunction (classical Cushing's disease) and metabolic syndrome (peripheral Cushing's Syndrom) in horses. Adv Vet Derm. 2005; 5 159-169 TÄ Jasmin-Isabelle MichuttaDr. Robert SchmitzProf. Dr. Heidrun Gehlen Klinik für Pferde, Allgemeine Chirurgie und Radiologie der Freien Universität Berlin Oertzenweg 19 b 14165 Berlin Email: michutta.ji@vetmed.fu-berlin.de Supplementary Material Supplementary Material References