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Planta Med 2012; 78(1): 52-58
DOI: 10.1055/s-0031-1280218
Natural Product Chemistry
Original Papers
© Georg Thieme Verlag KG Stuttgart · New York

19-Oxygenated ent-Kaurane Diterpenoids from Isodon pharicus

Yong Zhao1 , 2 , Jian-Xin Pu1 , Sheng-Xiong Huang1 , Li-Sheng Ding3 , Li-Mei Li1 , Xian Li1 , Li-Bin Yang1 , Wei-Lie Xiao1 , Ying-Li Wu4 , Guo-Qiang Chen4 , Han-Dong Sun1
  • 1State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, People's Republic of China
  • 2College of Chemistry and Engineering, Yunnan Normal University, Kunming, People's Republic of China
  • 3Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu, People's Republic of China
  • 4Department of Pathophysiology and Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education, Shanghai Jiao-Tong University School of Medicine (SJTU-SM) College, Shanghai, People's Republic of China
Further Information

Publication History

received April 26, 2011 revised July 30, 2011

accepted August 10, 2011

Publication Date:
30 September 2011 (online)

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Abstract

Eight new 19-oxygenated ent-kaurane diterpenoids (1–8) were isolated from the aerial parts of Isodon pharicus. Their structures were determined by means of extensive spectroscopic techniques including interpretation of 1D and 2D NMR spectra. Selected compounds were evaluated for their cytotoxicity against NB4, A549, PC-3, MCF-7, and SH-SY5Y cell lines.

Key words

Lamiaceae - Isodon pharicus - diterpenoid - cytotoxicity

Supporting Information

References

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Prof. Han-Dong Sun

State Key Laboratory of Phytochemistry and Plant Resources in West China
Kunming Institute of Botany
Chinese Academy of Sciences

Lanhei Road 132

Kunming 650204

People's Republic of China

Phone: +86 871 5 22 32 51

Fax: +86 871 5 21 63 43

Email: hdsun@mail.kib.ac.cn

Jian-Xin Pu

State Key Laboratory of Phytochemistry and Plant Resources in West China
Kunming Institute of Botany
Chinese Academy of Sciences

Lanhei Road 132

Kunming 650204

People's Republic of China

Phone: +86 871 5 22 32 51

Fax: +86 871 5 21 63 43

Email: pujianxin@mail.kib.ac.cn