Planta Med 2012; 78(1): 76-78
DOI: 10.1055/s-0031-1280251
Natural Product Chemistry
Letters
© Georg Thieme Verlag KG Stuttgart · New York

Neuraminidase Inhibitory Polyketides from the Marine-derived Fungus Phoma herbarum

Gao Fei Zhang1 , 2 , Wen Bo Han1 , Jiang Tao Cui1 , Seik Weng Ng3 , Zhi Kai Guo1 , Ren Xiang Tan1 , Hui Ming Ge1
  • 1Institute of Functional Biomolecules, State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing, China
  • 2Shenzhen Institute for Drug Control, Shenzhen, China
  • 3Department of Chemistry, University of Malaya, Kuala Lumpur, Malaysia
Further Information

Publication History

received April 12, 2011 revised July 28, 2011

accepted August 24, 2011

Publication Date:
27 September 2011 (online)

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Abstract

Two new polyketides, arthropsadiol C (1) and massarilactone H (2), together with six known derivatives (38) were isolated from the culture broth of the marine-derived fungus Phoma herbarum. Their structures were elucidated on the basis of spectroscopic methods, including 2D NMR techniques. Compounds 2, 4, 5, and 8 showed moderate neuraminidase inhibitory activity with IC50 values ranging from 4.15 to 9.16 µM.

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Associate Prof. Dr. Hui Ming Ge

Institute of Functional Biomolecules
State Key Laboratory of Pharmaceutical Biotechnology
Nanjing University

22 Hankou Road

Nanjing 210093

China

Phone: +86 25 83 59 32 01

Fax: +86 25 83 59 32 01

Email: hmge@nju.edu.cn