Planta Med 2012; 78(2): 135-140
DOI: 10.1055/s-0031-1280269
Pharmakokinetic Investigations
Original Papers
© Georg Thieme Verlag KG Stuttgart · New York

Influence of Co-Administered Danshensu on Pharmacokinetic Fate and Tissue Distribution of Paeonol in Rats

Hua Li1 , Siwang Wang1 , Bangle Zhang2 , Yanhua Xie1 , Jianbo Wang1 , Qian Yang1 , Wei Cao1 , Jing Hu1 , Linrui Duan1
  • 1Institute of Materia Medica, School of Pharmacy, Fourth Military Medical University, Xi'an, People's Republic of China
  • 2Department of Pharmaceutics, School of Pharmacy, Fourth Military Medical University, Xi'an, People's Republic of China
Further Information

Publication History

received August 16, 2011 revised Sept. 13, 2011

accepted Sept. 15, 2011

Publication Date:
06 October 2011 (online)

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Abstract

Cortex Moutan (root bark of Paeonia suffruticosa Andrew) and Radix Salviae miltiorrhizae (root and rhizome of Salvia miltiorrhiza Bunge) are two herbs widely used in traditional Chinese medicine (TCM) to treat cerebrovascular and cardiovascular diseases. In clinical practice, these two herbs are prescribed together. Studies on the pharmacokinetic interaction between the active constituents of these two herbs (paeonol and danshensu, respectively) can provide substantial foundation for understanding its mechanism and empirical evidence to support the clinical practice. A simple and sensitive high-performance liquid chromatographic (HPLC) method coupled with ultraviolet detector was developed for determination of paeonol in plasma and different tissues (heart, liver, spleen, lung, kidney, and brain) of male Sprague-Dawley rats. When co-administering danshensu, the peak plasma concentration of paeonol was decreased (p < 0.01), the mean residence time (MRT) was prolonged (p < 0.001), the volume of distribution (Vd/F) was increased (p < 0.001), and the concentrations of paeonol in heart, brain, and lung were dramatically increased (p < 0.01 or p < 0.001), compared with these values for rats administered paeonol alone. The results showed that the co-administration of danshensu could alter pharmacokinetic fate and tissue distribution of paeonol in rats, especially in heart and brain, providing substantial foundation for the investigation of the impact of danshensu on paeonol in clinical applications.

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References

Prof. Siwang Wang

Institute of Materia Medica, School of Pharmacy
Fourth Military Medical University

169 West Changle Road

710032 Xi'an

People's Republic of China

Phone: +86 29 8477 47 48

Fax: +86 29 8322 47 90

Email: wangsiw@hotmail.com

Associate Prof. Bangle Zhang

Department of Pharmaceutics, School of Pharmacy
Fourth Military Medical University

169 West Changle Road

710032 Xi'an

People's Republic of China

Phone: +86 29 8477 45 56

Fax: +86 29 8477 45 52

Email: blezhang@hotmail.com