Pharmacokinetic Comparisons of Albiflorin and Paeoniflorin after Oral Administration of Shaoyao-Gancao-Tang and Single Herb Paeony Decoction to Rats

Pingping Gan; Meizuo Zhong; Xi Huang; Ming Sun; Yang Wang; Yanying Xiao; Chang Zeng; Qiongjing Yuan; Zhaoqian Liu; Honghao Zhou

doi:10.1055/s-0031-1280366

Planta Medica, Inhaltsverzeichnis

Planta Med 2012; 78(3): 237-243
DOI: 10.1055/s-0031-1280366

Pharmacokinetic Investigations

Original Papers
© Georg Thieme Verlag KG Stuttgart · New York

Pharmacokinetic Comparisons of Albiflorin and Paeoniflorin after Oral Administration of Shaoyao-Gancao-Tang and Single Herb Paeony Decoction to Rats

Pingping Gan¹ , Meizuo Zhong¹ , Xi Huang² , Ming Sun³ , Yang Wang² , Yanying Xiao⁴ , Chang Zeng⁵ , Qiongjing Yuan⁶ , Zhaoqian Liu⁷ , Honghao Zhou⁷

¹Department of Oncology, Xiangya Hospital, Central South University, Changsha, China
²Laboratory of Ethnopharmacology, Institute of Integrated Traditional Medicine and Western Medicine, Xiangya Hospital, Central South University, Changsha, China
³Department of Cardiovascular Medicine, Xiangya Hospital, Central South University, Changsha, China
⁴Department of Anesthesiology, Second Xiangya Hospital, Central South University, Changsha, China
⁵Department of Neurology, Xiangya Hospital, Central South University, Changsha, China
⁶Department of Nephrology, Xiangya Hospital, Central South University, Changsha, China
⁷Institute of Clinical Pharmacology, Hunan Key Laboratory of Pharmacogenetics, Central South University, Changsha, China

Abstract

Shaoyao-Gancao-Tang (SGT) is a traditional Chinese prescription containing Radix Paeoniae alba and Radix Glycyrrhizae and is commonly used to relieve pains. Albiflorin and paeoniflorin are the main effective compounds of Radix Paeoniae alba, and the pharmacokinetic differences of the two compounds in rats after oral administration of SGT and single herb Paeony decoction were studied. At different time points (5, 10, 15, 20, 30, 45, 60, 90, 120, 180, 240, 360, and 540 min) after administration, plasma concentrations of albiflorin and paeoniflorin were determined using a simple and reliable UPLC method, and main pharmacokinetic parameters were evaluated. It was found that there were significant differences (p < 0.05 or p < 0.01) between the two groups. The results indicated that some components in the other ingredient herb of SGT (Radix Glycyrrhizae) had a pharmacokinetic interaction with albiflorin and paeoniflorin and hence reduced their systematic exposure level.

Key words

Shaoyao-Gancao-Tang - albiflorin - paeoniflorin - pharmacokinetic - UPLC

Volltext

Referenzen

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Prof. Dr. Meizuo Zhong

Department of Oncology, Xiangya Hospital
Central South University

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