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Planta Med 2012; 78(3): 237-243
DOI: 10.1055/s-0031-1280366
Pharmacokinetic Investigations
Original Papers
© Georg Thieme Verlag KG Stuttgart · New York

Pharmacokinetic Comparisons of Albiflorin and Paeoniflorin after Oral Administration of Shaoyao-Gancao-Tang and Single Herb Paeony Decoction to Rats

Pingping Gan1 , Meizuo Zhong1 , Xi Huang2 , Ming Sun3 , Yang Wang2 , Yanying Xiao4 , Chang Zeng5 , Qiongjing Yuan6 , Zhaoqian Liu7 , Honghao Zhou7
  • 1Department of Oncology, Xiangya Hospital, Central South University, Changsha, China
  • 2Laboratory of Ethnopharmacology, Institute of Integrated Traditional Medicine and Western Medicine, Xiangya Hospital, Central South University, Changsha, China
  • 3Department of Cardiovascular Medicine, Xiangya Hospital, Central South University, Changsha, China
  • 4Department of Anesthesiology, Second Xiangya Hospital, Central South University, Changsha, China
  • 5Department of Neurology, Xiangya Hospital, Central South University, Changsha, China
  • 6Department of Nephrology, Xiangya Hospital, Central South University, Changsha, China
  • 7Institute of Clinical Pharmacology, Hunan Key Laboratory of Pharmacogenetics, Central South University, Changsha, China
Further Information

Publication History

received Nov. 25, 2010 revised Sept. 10, 2011

accepted October 24, 2011

Publication Date:
12 December 2011 (online)

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Abstract

Shaoyao-Gancao-Tang (SGT) is a traditional Chinese prescription containing Radix Paeoniae alba and Radix Glycyrrhizae and is commonly used to relieve pains. Albiflorin and paeoniflorin are the main effective compounds of Radix Paeoniae alba, and the pharmacokinetic differences of the two compounds in rats after oral administration of SGT and single herb Paeony decoction were studied. At different time points (5, 10, 15, 20, 30, 45, 60, 90, 120, 180, 240, 360, and 540 min) after administration, plasma concentrations of albiflorin and paeoniflorin were determined using a simple and reliable UPLC method, and main pharmacokinetic parameters were evaluated. It was found that there were significant differences (p < 0.05 or p < 0.01) between the two groups. The results indicated that some components in the other ingredient herb of SGT (Radix Glycyrrhizae) had a pharmacokinetic interaction with albiflorin and paeoniflorin and hence reduced their systematic exposure level.

Key words

Shaoyao-Gancao-Tang - albiflorin - paeoniflorin - pharmacokinetic - UPLC

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Prof. Dr. Meizuo Zhong

Department of Oncology, Xiangya Hospital
Central South University

87 Xiangya Road

Changsha, Hunan 410008

China

Phone: +86 731 84 32 73 74

Email: meizuozhong@163.com