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Int J Sports Med 2011; 32(11): 869-874
DOI: 10.1055/s-0031-1280775
Clinical Sciences
Georg Thieme Verlag KG Stuttgart · New York

The Antinociceptive Efficacy of HWTX-I Epidurally Administered in Rheumatoid Arthritis Rats

Z. Wen tao
1   Hunan Normal University, College of Physical Education, Changsha, China
3   Hunan Supervision and Inspection Institute for Product Quality, Changsha, China
,
T. Gu yang
1   Hunan Normal University, College of Physical Education, Changsha, China
,
R. Ying
1   Hunan Normal University, College of Physical Education, Changsha, China
,
W. Mao cai
1   Hunan Normal University, College of Physical Education, Changsha, China
,
L. Lin
1   Hunan Normal University, College of Physical Education, Changsha, China
,
L. Chi miao
2   Central Hospital of Shaoyang, Shaoyang, China
,
H. Peng
1   Hunan Normal University, College of Physical Education, Changsha, China
,
C. Jia Qin
1   Hunan Normal University, College of Physical Education, Changsha, China
› Author Affiliations
Further Information

Publication History



accepted after revision 17 May 2011

Publication Date:
03 November 2011 (online)

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Abstract

Rheumatoid arthritis (RA) is one of the inflammatory kinds of arthritis in the clinical situation, and cytosolic Ca2+ overload has been proposed as one of the primary factors for many inflammatory cells activation, which lead to relative enzymes and inflammatory factors release. It is therefore accepted that Ca2+ channel blockers can protect joint injury from inflammation. In the present study we investigated the possible molecular mechanism of the antinociceptive efficacy of HWTX-I, a spider peptide toxin blocking Ca2+ channels, on the rat rheumatoid arthritis model. Our study demonstrates that HWTX-I can relieve pain in the inflammatory joints and eliminate arthrocele to some degree. Moreover, HWTX-I can also decrease the concentration of tumour necrosis factor α (TNF-α) and increase the concentration of interleukin 4(IL-4) and interleukin 10(IL-10) in rat’s serum. HWTX-I can also decrease the mRNA expression level of related factors of TNF-α, interleukin 1β (IL-1β) and interleukin 6(IL-6) in inflammatory pathways in rheumatoid arthritis. Therefore, the present results show that the epidural administration of HWTX-I is effective in antinociception in the rat model of rheumatoid arthritis, which may act through its inhibition on certain inflammatory pathways.

Key words

HWTX-I - rheumatoid arthritis - calcium channel blocker - antinociception
 

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