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Semin Respir Crit Care Med 2011; 32(5): 651-660
DOI: 10.1055/s-0031-1287873
© Thieme Medical Publishers

Hematologic Failure

Marcel Levi1 , Marcus Schultz2
  • 1Department of Vascular Medicine/Internal Medicine, University of Amsterdam, The Netherlands
  • 2Department of Intensive Care, Academic Medical Centre, University of Amsterdam, The Netherlands
Further Information

Publication History

Publication Date:
11 October 2011 (online)

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ABSTRACT

Hematologic factors, in particular platelets and the coagulation system, play an important role in the pathogenesis of organ failure in the intensive care unit. Failure of these hematologic systems is common in intensive care patients and may range from isolated thrombocytopenia or prolonged global clotting tests to complex defects, such as disseminated intravascular coagulation. There are many causes for a deranged coagulation in critically ill patients, and each of these underlying disorders may require specific therapeutic management. Hence, a proper differential diagnosis and initiation of adequate (supportive) treatment strategies are crucial to reduce morbidity and mortality in critically ill patients with coagulation abnormalities.

KEYWORDS

Coagulation - platelets - intensive care - disseminated intravascular coagulation - thrombotic microangiopathy - heparin-induced thrombocytopenia - bleeding

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Marcel LeviM.D. Ph.D. 

Department of Vascular Medicine/Internal Medicine, Academic Medical Centre F-4

Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands

Email: m.m.levi@amc.uva.nl