Abstract
An iterative strategy to the 1,3-polyol motif is described. The
use of the catalytic asymmetric Overman esterification for the construction
of all stereogenic centers is broadly examined as are the sequences
to extend the developing polyol chain. The iterative strategies
are applied to the total syntheses of rugulactone and polyrhacitides
A and B.
1 Introduction
2 Results and Discussion
2.1 Chain Elongation via RCM (Cycle A)
2.2 Total Synthesis of Rugulactone
2.3 Chain Elongation via Ando Olefination (Cycle B) and Total Syntheses
of Polyrhacitides A and B
2.4 Useful Variants
3 Conclusions
Key words
polyols - palladium - catalysis - natural
products - esters
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