Abstract
Efficient and divergent one-pot synthesis of cyclopropyl amides
and esters from readily available 1-acetylcyclopropanes via iodoform
reaction based on the selection of reaction conditions is reported.
A series of substituted cyclopropyl amides were synthesized from
1-acetylcyclopropanes, iodine, and ammonia in water in the presence
of K2 CO3 in good yields, whereas substituted
cyclopropyl esters were obtained from the reaction of 1-acetylcyclopropanes with
iodine and alcohols in the presence of DBU.
Key words
cyclopropanes - iodoform reaction - iodine - amide - water
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