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Synthesis 2012(7): 1119-1125
DOI: 10.1055/s-0031-1289717
DOI: 10.1055/s-0031-1289717
PAPER
© Georg Thieme Verlag
Stuttgart ˙ New York
Base-Mediated Tandem Reaction of α-Aryloxyacetophenones with Phosphonates: Selective Synthesis of Enol Phosphates
Further Information
Publication History
Received
21 December 2011
Publication Date:
17 February 2012 (online)


Abstract
A new, simple method for the synthesis of enol phosphates by base-mediated tandem reaction of α-aryloxyacetophenones with phosphonates is described. In the presence of Cs2CO3, a variety of α-aryloxyacetophenones smoothly underwent the sequential O-P bond-forming/C-O bond cleavage/isomerization tandem reaction with phosphonates at room temperature, providing the corresponding enol phosphates in moderate to excellent yields.
Key words
base - tandem reaction - α-aryloxyacetophenone - phosphonate - enol phosphate
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