Base-Mediated Tandem Reaction of α-Aryloxyacetophenones with Phosphonates: Selective Synthesis of Enol Phosphates

Abstract

A new, simple method for the synthesis of enol phosphates by base-mediated tandem reaction of α-aryloxyacetophenones with phosphonates is described. In the presence of Cs₂CO₃, a variety of α-aryloxyacetophenones smoothly underwent the sequential O-P bond-forming/C-O bond cleavage/isomerization tandem reaction with phosphonates at room temperature, providing the corresponding enol phosphates in moderate to excellent yields.

Key words

base - tandem reaction - α-aryloxyacetophenone - phosphonate - enol phosphate

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