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Synlett 2012; 23(8): 1103-1107
DOI: 10.1055/s-0031-1290765
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© Georg Thieme Verlag Stuttgart · New York

The Use of Tertiary Alkylmagnesium Nucleophiles in Ni-Catalyzed Cross-Coupling Reactions

Amruta Joshi-Pangu
Department of Chemistry, The City College of New York, 160 Convent Avenue, New York, NY 10031, USA, Fax: +1(212)6506107   Email: mbiscoe@ccny.cuny.edu
,
Mark R. Biscoe*
Department of Chemistry, The City College of New York, 160 Convent Avenue, New York, NY 10031, USA, Fax: +1(212)6506107   Email: mbiscoe@ccny.cuny.edu
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Further Information

Publication History

Received: 23 January 2012

Accepted: 08 February 2012

Publication Date:
20 April 2012 (online)

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Abstract

Nickel-catalyzed cross-coupling reactions of unactivated tertiary alkyl nucleophiles and aryl bromides have been developed using N-heterocyclic carbene ligands. These processes are reviewed alongside earlier attempts to employ unactivated tertiary alkyl nucleophiles in cross-coupling reactions. Potential mechanisms for the transformations, and future challenges in this field are discussed.

Key words

nickel - cross-coupling - transition metals - homogeneous catalysis - Grignard reaction
 

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