One-Pot, Pseudo Five-Component Synthesis of Spirooxindole Derivatives 
Containing Fused 1,4-Dihydropyridines in Water

Abdolali Alizadeh; Azadeh Mikaeili; Tahereh Firuzyar

doi:10.1055/s-0031-1290884

Synthesis, Inhaltsverzeichnis

Synthesis 2012; 44(9): 1380-1384
DOI: 10.1055/s-0031-1290884

paper

One-Pot, Pseudo Five-Component Synthesis of Spirooxindole Derivatives Containing Fused 1,4-Dihydropyridines in Water

Abdolali Alizadeh*

Department of Chemistry, Tarbiat Modares University, P. O. Box 14115-175, Tehran, Iran, Fax: +98(21)88006544 eMail: abdol_alizad@yahoo.com eMail: aalizadeh@modares.ac.ir

,

Azadeh Mikaeili

Department of Chemistry, Tarbiat Modares University, P. O. Box 14115-175, Tehran, Iran, Fax: +98(21)88006544 eMail: abdol_alizad@yahoo.com eMail: aalizadeh@modares.ac.ir

,

Tahereh Firuzyar

Department of Chemistry, Tarbiat Modares University, P. O. Box 14115-175, Tehran, Iran, Fax: +98(21)88006544 eMail: abdol_alizad@yahoo.com eMail: aalizadeh@modares.ac.ir

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Abstract

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Abstract

An efficient, facile, and simple route for the preparation of spirooxindole-containing fused 1,4-dihydropyridine derivatives through a one-pot, pseudo five-component condensation reaction of isatin or its derivatives, 1,1-bis(methylthio)-2-nitroethylene, 1,3-dicarbonyl compounds, and two equivalents of ammonia in water is reported. The merits of this method include the use of water as a green solvent, and inexpensive and easily available starting materials and catalyst, the high yield of products, and the straightforward work-up.

Key words

ammonia - fused-ring systems - natural products - spirooxindole - water - multicomponent reactions

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Referenzen

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