Formal [4+1] Annulation of Cyclopropyl Amides and Water Mediated by Lewis Acid: A Novel Entry to γ-Butyrolactones

Abstract

An efficient one-pot synthesis of substituted γ-butyrolactones from cyclopropyl amides mediated by the Lewis acid SnCl₄·5H₂O is reported. A mechanism involving a tandem ring-opening reaction and intramolecular cyclization reaction is proposed.

Key words

γ-lactones - cyclopropyl amides - Lewis acids - synthetic methods - water

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