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Semin Reprod Med 2011; 29(6): 482-490
DOI: 10.1055/s-0031-1293202
© Thieme Medical Publishers

Endocrinology and Recurrent Early Pregnancy Loss

M. Leah Smith1 , Danny J. Schust1
  • 1Department of Obstetrics, Gynecology and Women's Health, University of Missouri School of Medicine, Columbia, Missouri
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Publication History

Publication Date:
08 December 2011 (online)

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ABSTRACT

Endocrine disorders have been frequently linked to recurrent pregnancy loss (RPL). Because embryo attachment and early implantation are exquisitely controlled by the local hormonal milieu, endocrine-related pregnancy failures are likely to occur early in gestation. Thyroid disorders, luteal phase defects, and polycystic ovary syndrome are the endocrine abnormalities most commonly associated with RPL. In this review we discuss new concepts in the pathophysiology and treatment of these diseases with the ultimate goal of improving pregnancy maintenance. We have also included our recommendations on testing and treatment of women with isolated and repeated pregnancy failure that is believed to be at least partially mediated by newly defined hypothyroidism, thyroid autoimmunity, luteal phase defects, obesity, and polycystic ovary syndrome.

KEYWORDS

Thyroid autoantibodies - polycystic ovarian syndrome - luteal phase defect - recurrent pregnancy loss

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Danny J. SchustM.D. 

Department of Obstetrics, Gynecology and Women's Health, University of Missouri School of Medicine

500 North Keene Street, Suite 203, Columbia, MO 65201

Email: schustd@health.missouri.edu