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Horm Metab Res 2012; 44(03): 194-201
DOI: 10.1055/s-0031-1295461
Review
© Georg Thieme Verlag KG Stuttgart · New York

Aldosterone and the Kidney

V. G. Fourkiotis
1   Department of Clinical Endocrinology, Charité Campus Mitte, Charité University Medicine Berlin, Berlin, Germany
,
G. Hanslik
1   Department of Clinical Endocrinology, Charité Campus Mitte, Charité University Medicine Berlin, Berlin, Germany
,
F. Hanusch
1   Department of Clinical Endocrinology, Charité Campus Mitte, Charité University Medicine Berlin, Berlin, Germany
,
J. Lepenies
2   KfH Dialysis Center Bismarckstrasse, Berlin, Germany
,
M. Quinkler
1   Department of Clinical Endocrinology, Charité Campus Mitte, Charité University Medicine Berlin, Berlin, Germany
› Author Affiliations
Further Information

Publication History

received 30 August 2011

accepted 26 October 2011

Publication Date:
07 December 2011 (online)

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Abstract

The mineralocorticoid aldosterone is a key regulator of blood pressure, fluid and electrolyte homeostasis, and acts via the mineralocorticoid receptor (MR). In recent years, an increasing number of studies revealed deleterious effects of aldosterone via its receptor. Especially in patients with primary hyperaldosteronism (PHA) a significant higher risk of developing cardiovascular comorbidities and comortalities was reported. Also renal insufficiency is clearly increased in patients with PHA indicating a role of aldosterone and the MR in the pathogenesis of renal injury. It has been shown that aldosterone in combination with an elevated salt intake, leads to renal inflammation, fibrosis, podocyte injury, and mesangial cell proliferation. This review focuses on the current knowledge of aldosterone effects in the kidney and highlights this topic from 2 perspectives: from clinical medicine and from experimental studies.

Key words

aldosterone - chronic kidney disease - primary hyperaldosteronism - albuminuria - renal inflammation
 

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