Total Antioxidant Capacity and Total Oxidant Status in Perinatal Asphyxia in Relation to Neurological Outcome

O. Aydemir; M. Akar; N. Uras; Z. Eras; O. Erdeve; S. S. Oguz; U. Dilmen

doi:10.1055/s-0031-1295480

Neuropediatrics, Inhaltsverzeichnis

Neuropediatrics 2011; 42(06): 222-226
DOI: 10.1055/s-0031-1295480

Original Article

Total Antioxidant Capacity and Total Oxidant Status in Perinatal Asphyxia in Relation to Neurological Outcome

O. Aydemir

¹Department of Neonatology, Zekai Tahir Burak Maternity Teaching Hospital, Ankara, Turkey

,

M. Akar

¹Department of Neonatology, Zekai Tahir Burak Maternity Teaching Hospital, Ankara, Turkey

,

N. Uras

¹Department of Neonatology, Zekai Tahir Burak Maternity Teaching Hospital, Ankara, Turkey

,

Z. Eras

²Department of Developmental Pediatrics, Zekai Tahir Burak Maternity Teaching Hospital, Ankara, Turkey

,

O. Erdeve

¹Department of Neonatology, Zekai Tahir Burak Maternity Teaching Hospital, Ankara, Turkey

,

S. S. Oguz

¹Department of Neonatology, Zekai Tahir Burak Maternity Teaching Hospital, Ankara, Turkey

,

U. Dilmen

¹Department of Neonatology, Zekai Tahir Burak Maternity Teaching Hospital, Ankara, Turkey

› Institutsangaben

Abstract

This study aimed to investigate the global oxidant/antioxidant status of infants with perinatal asphyxia and its relation to neurological outcomes. A prospective controlled study including term infants with perinatal asphyxia was conducted. Blood samples were obtained from patients and controls at 6–24 h and on the 3^rd day of life for TAC and TOS measurement and OSI values were calculated. Neurodevelopment was evaluated at 12 months of age in survivors using Bayley scales of infant development II (BSID II). 17 term infants with perinatal asphyxia and 17 healthy controls were enrolled. On the first day of life TAC, TOS and OSI were significantly higher in patients with perinatal asphyxia (p<0.001). Total antioxidant capacity decreased significantly on day 3 compared to first day of life in the patient group (p=0.04). Infants with seizures and abnormal amplitude-integrated electroencephalography recordings had higher TOS and OSI levels in the 1^st day. There was no correlation between TAC, TOS and OSI levels and BSID II scores. In conclusion oxidant/antioxidant balance is disturbed in favour of oxidants in perinatal asphyxia. Degree of oxidative stress is related to severity of neurological involvement in the first days of life.

Key words

hypoxic-ischemic encephalopathy - newborn - neurological outcome - oxidative stress - seizures

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Referenzen

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