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Arzneimittelforschung 2011; 61(9): 521-526
DOI: 10.1055/s-0031-1296238
Antibiotics · Antimycotics · Antiparasitics · Antiviral Drugs · Chemotherapeutics · Cytostatics
Editio Cantor Verlag Aulendorf (Germany)

Design and synthesis of some novel hydrazide, 1,2-dihydropyridine, chromene derivatives carrying biologically active sulfone moieties with potential anticancer activity

Mahmoud S Bashandy
1   Department of Chemistry, Faculty of Science, Al-Azhar University, Nasr City, Cairo, Egypt
,
Mansour S. Al-Said
2   Medicinal, Aromatic and Poisonous Plants Research Center (MAPPRC), College of Pharmacy, King Saud University, Riyadh, Saudi Arabia
,
Saleh I. Al-Qasoumi
3   Department of Pharmacognosy, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia
,
Mostafa M. Ghorab
2   Medicinal, Aromatic and Poisonous Plants Research Center (MAPPRC), College of Pharmacy, King Saud University, Riyadh, Saudi Arabia
4   Department of Drug Radiation Research, National Center for Radiation Research and Technology, Nasr City, Cairo, Egypt
› Author Affiliations
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Publication History

Publication Date:
03 December 2011 (online)

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Abstract

This paper describes the synthesis of some novel sulfones having biologically active hydrazides (4-9, 22, 23, 26 and 27), hydrazonoyl cyanide (24), 1,2-dihydro-pyridines (16-21), chromene (28) and benzochromene (29) moieties starting with 1-[4-(piperidin-1-ylsulfonyl)phenyl]-ethanone 1. The structures of the the newly synthesized compounds were confirmed by elemental analysis, IR, 1H NMR and 13C NMR. All the newly synthesized compounds were evaluated for their in vitro anticancer activity against breast cancer cell line (MCF7).

Key words

Anticancer activity - Breast cancer cell line - Chromene derivatives - 1,2-Dihydropyridine - Hydrazide derivatives - Sulfone derivatives
 

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