Abstract
Ten new triterpenoids, schiglausins A–J (1 –10 ), as well as four known compounds, were isolated from the stems of Schisandra glaucescens . Their structures were elucidated on the basis of spectroscopic methods, including extensive NMR spectra and CD experiment. Compound 8 was determined to be a norlanostane triterpenoid. The crystal structure of compound 1 has been determined using single-crystal X-ray analysis while its absolute configuration was assigned on the basis of the CD spectrum. All isolates were tested for their FXR agonistic and antagonistic effects.
Key words
lanostane triterpenoids - Schisandraceae -
Schisandra glaucescens
- FXR
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Prof. Han-Dong Sun Dr. Wei-Lie Xiao
State Key Laboratory of Phytochemistry and Plant Resources in West China Kunming Institute of Botany Chinese Academy of Sciences
Lanhei Road 132
Kunming 650201
People's Republic of China
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