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DOI: 10.1055/s-0031-1298214
© Georg Thieme Verlag KG Stuttgart · New York
Lanostane Triterpenoids from the Stems of Schisandra glaucescens
Publication History
received July 15, 2011
revised Dec. 28, 2011
accepted January 9, 2012
Publication Date:
26 January 2012 (online)

Abstract
Ten new triterpenoids, schiglausins A–J (1–10), as well as four known compounds, were isolated from the stems of Schisandra glaucescens. Their structures were elucidated on the basis of spectroscopic methods, including extensive NMR spectra and CD experiment. Compound 8 was determined to be a norlanostane triterpenoid. The crystal structure of compound 1 has been determined using single-crystal X-ray analysis while its absolute configuration was assigned on the basis of the CD spectrum. All isolates were tested for their FXR agonistic and antagonistic effects.
Key words
lanostane triterpenoids - Schisandraceae - Schisandra glaucescens - FXR
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Prof. Han-Dong Sun
Dr. Wei-Lie Xiao
State Key Laboratory of Phytochemistry and Plant Resources in West China
Kunming Institute of Botany
Chinese Academy of Sciences
Lanhei Road 132
Kunming 650201
People's Republic of China
Phone: +86 87 15 22 32 51
Fax: +86 87 15 21 63 43
Email: hdsun@mail.kib.ac.cn
Email: xwl@mail.kib.ac.cn