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Thorac Cardiovasc Surg 2012; 60(01): 057-063
DOI: 10.1055/s-0031-1299574
Original Cardiovascular
Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

Renal Graft Outcome in Combined Heart–Kidney Transplantation Compared to Kidney Transplantation Alone: A Single-Center, Matched-Control Study

L. Kebschull
1   Department of General and Visceral Surgery, University of Muenster, Muenster, Germany
*   Both authors contributed equally to this work
,
C. Schleicher
1   Department of General and Visceral Surgery, University of Muenster, Muenster, Germany
*   Both authors contributed equally to this work
,
D. Palmes
1   Department of General and Visceral Surgery, University of Muenster, Muenster, Germany
,
J. Sindermann
2   Department of Heart, Thoracic, and Vascular Surgery, University of Muenster, Muenster, Germany
,
B. Suwelack
3   Department of Internal Medicine D, University of Muenster, Muenster, Germany
,
N. Senninger
1   Department of General and Visceral Surgery, University of Muenster, Muenster, Germany
,
H. Wolters
1   Department of General and Visceral Surgery, University of Muenster, Muenster, Germany
› Author Affiliations
Further Information

Publication History

09 June 2011

23 September 2011

Publication Date:
10 January 2012 (online)

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Corrected by:

Addendum to: Renal graft outcome in combined heart-kidney transplantation compared to kidney transplantation alone: a single-center, matched-control study.Thorac Cardiovasc Surg 2013; 61(04): 374-374
DOI: 10.1055/s-0033-1343840

Abstract

Background Renal allograft outcome in heart–kidney transplantation (HKTx) might be affected by hemodynamic instability and high levels of calcineurin inhibitor-dependent immunosuppression.

Methods From November 1999 to March 2008, 13 patients who received HKTx were compared with a matched control group of 13 kidney transplantation (KTx) recipients with similar cardiovascular risk factors. Graft function, rejection periods, and patient survival were analyzed.

Results Renal allograft rejection was noted in three patients (23%) after HKTx and in four patients (31%) after KTx. Serum creatinine levels were comparable at 1 week, 1 month, 1, 2, and 3 years after transplantation. Patient survival rates at 1, 2, and 3 years were 100% for HKTx recipients and 100, 92, and 92% for isolated KTx patients. Graft survival was 92% at 1, 2, and 3 years after HKTx and 100% at 1 year and 92% at 2 and 3 years after isolated KTx.

Conclusions Our results with excellent long-term graft function and survival after combined HKTx indicate that this procedure is a valuable option for a growing number of patients suffering from coexistent cardiac and renal failure.

Keywords

combined transplantation - heart transplantation - kidney transplantation - renal allograft function - transplantation outcome
 

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