Zentralblatt für Chirurgie, Inhaltsverzeichnis Zentralbl Chir 2011; 136(06): 545-548DOI: 10.1055/s-0031-1299608 Aktuelle Chirurgie Georg Thieme Verlag KG Stuttgart · New York Sepsis – Boten der Gefahr Diagnostische und therapeutische Bedeutung der Sepsismarker. Thomas Iber , Kai Zacharowski Artikel empfehlen Abstract Volltext Referenzen Literatur 1 Engel C, Brunkhorst FM, Bone HG et al. Epidemiology of sepsis in Germany. Intensive Care Med 2007; 33: 606-618 2 Kumar A, Roberts D, Wood KE. Duration of hypotension before initiation of effective antimicrobial therapy is the critical determinant of survival in human septic shock. Crit Care Med 2006; 34: 1589-1596 3 Pierrakkos C, Vincent JL. Sepsis biomarkers: a review. Critical Care 2010; 14: R15 4 Bone RC, Balk RA, Cerra FB et al. Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. The ACCP/SCCM Consensus Conference Committee. Chest 1992; 101: 1644-1655 5 Remick DG. Cytokine therapeutics for the treatment of sepsis: why has nothing worked?. Curr Pharm Des 2003; 9: 75-82 6 Rittirsch D, Flierl MA, Ward PA. Harmful molecular mechanisms in sepsis. Nat R Immunol 2008; 8: 776-787 7 Petzelbauer P, Zacharowski P, Friedl P et al. The peptide Bb15-42 protects the myocardium against ischemia/reperfusion injury. N Med 2005; 11: 298-304 8 Gröger M, Pasteiner W, Ignatyev G et al. Peptide Bb15-42 preserves endothelial barrier function in shock. PLos One. 2009; 4 (Suppl. 04) e5391 Epub 2009 Apr 29 9 Kibe S, Admas K, Barlow G. Diagnostic and prognostic biomarkers od sepsis in critical care. J Antimicrob Chemother 2011; 66 (Suppl. 02) 33-40 10 Harbarth S, Holeckova K, Froidevaux C et al. Diagnostic value of procalcitonin, interleukin-6 and interleukin-8 in critically ill patients admitted with suspected sepsis. Am J Resp Crit Care Med 2001; 164: 396-402 11 Sakr Y, Burgett U, Nacul FE et al. Lipopolysaccharide binding protein in a surgical intensive care unit: a marker of sepsis?. Crit Care Med 2008; 36: 2014-2022