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Int J Sports Med 2012; 33(07): 572-579
DOI: 10.1055/s-0031-1301318
Clinical Sciences
© Georg Thieme Verlag KG Stuttgart · New York

Intervention of TLR4 Signal Pathway Cytokines in Severe Liver Injury with Obstructive Jaundice in Rats

L. Lin
1   Hunan Normal University, College of Physical Education, Changsha, China
,
W. M. Cai
1   Hunan Normal University, College of Physical Education, Changsha, China
,
C. J. Qin
1   Hunan Normal University, College of Physical Education, Changsha, China
,
L. C. Miao
2   Central Hospital of Shaoyang, Shaoyang, China
,
L. T. Yun
2   Central Hospital of Shaoyang, Shaoyang, China
,
Y. Hua
2   Central Hospital of Shaoyang, Shaoyang, China
,
L. Weilin
1   Hunan Normal University, College of Physical Education, Changsha, China
› Author Affiliations
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Publication History



accepted after revision 14 December 2011

Publication Date:
04 May 2012 (online)

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Abstract

Obstructive jaundice is a common surgical disease and a variety of end-stage severe liver injuries still lack effective treatments. Compared to traditional liver transplantation therapy, herbal treatment is noninvasive and has fewer side effects. Research results have shown that a modified major decoction of bupleurum can reduce the toxic reaction of obstructive jaundice, even though the mechanism is unclear. A period of chronic exercise training can significantly reduce TLR4 expression in mononuclear cells and the secretion of inflammatory cell factors. Our study administered a modified major decoction of bupleurum in combination with exercise in rats with obstructive jaundice and the results indicated that applying a major bupleurum decoction in combination with moderately intense aerobic exercise showed a beneficial effect on adjusting the expression of liver inflammatory cytokines, which thus improved immunity and finally reduced the liver injury of rats with obstructive jaundice.

Key words

modified major decoction of bupleurum - medium-intensity aerobic exercise - obstructive jaundice - TLR4
 

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