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Semin Respir Crit Care Med 2012; 33(01): 26-35
DOI: 10.1055/s-0032-1301732
Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

Sleep Disorders in Chronic Liver Disease

Sharon De Cruz
1   Division of Pulmonary, Critical Care, and Sleep Medicine, David Geffen School of Medicine at UCLA, Los Angeles, California.
,
Joseph Roland D. Espiritu
2   Division of Pulmonary, Critical Care, and Sleep Medicine, St. Louis University School of Medicine, St. Louis, Missouri.
,
Michelle Zeidler
1   Division of Pulmonary, Critical Care, and Sleep Medicine, David Geffen School of Medicine at UCLA, Los Angeles, California.
,
Tisha S. Wang
1   Division of Pulmonary, Critical Care, and Sleep Medicine, David Geffen School of Medicine at UCLA, Los Angeles, California.
› Author Affiliations
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Publication History

Publication Date:
23 March 2012 (online)

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Abstract

Sleep-related complaints and disturbances are increasingly recognized in the setting of chronic liver disease and have recently been shown to be an important prognostic factor in patients with advanced chronic liver disease. This article reviews the literature surrounding sleep disturbances and disorders in a variety of types of chronic liver disease. This includes the association of sleep disturbances with hepatitis C and antiviral therapy, primary biliary cirrhosis, and Wilson disease as well as the circadian rhythm abnormalities present in cirrhosis and hepatic encephalopathy. The association between chronic liver disease, particularly nonalcoholic fatty liver disease, and sleep-disordered breathing is also reviewed in detail.

Keywords

sleep apnea - hepatic cirrhosis - electroencephalogram - polysomnogram - circadian rhythm
 

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