Experimental and Clinical Endocrinology & Diabetes, Inhaltsverzeichnis Exp Clin Endocrinol Diabetes 2012; 120(04): 191-193DOI: 10.1055/s-0032-1304569 Mini-Review Series on Diabetes and its Complications © J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New York Murine Models of Diabetic Nephropathy V. Peters 1 Division of Metabolic Diseases, Centre for Paediatric and Adolescent Medicine, University of Heidelberg, Heidelberg, Germany , C. P. Schmitt 2 Division of Paediatric Nephrology, Centre for Paediatric and Adolescent Medicine, University of Heidelberg, Heidelberg, Germany › Institutsangaben Artikel empfehlen Abstract Artikel einzeln kaufen Abstract Diabetic nephropathy is the leading cause of end stage renal diseases worldwide. Even though several diabetic animal models exist, not a single one develops renal changes sufficiently reflecting those seen in humans. This review provides an overview on mouse models presenting with various features of diabetic nephropathy. The critical analysis and comparison of existing mouse models substantially enhances our understanding of the disease process and should provide a guide for choosing the most suitable mouse model for the investigation of diabetic nephropathy. Key words Key wordsdiabetes - obesity - leptin Volltext Referenzen References 1 Nawroth PP, Isermann B. Mechanisms of Diabetic Nephropathy – Old Buddies and Newcomers Part 1. Exp Clin Endocrin Diabetes 2010; 118: 571-576 2 Tesch GH, Lim AKH. Recent insights into diabetic renal injury from the db/db mouse model of type 2 diabetic nephropathy. Am J Physiol Renal Physiol 2011; 300 (02) F301-F310 3 Alpers CE, Hudkins KL. Mouse models of diabetic nephropathy. Curr Opin Nephrol Hypertens 2011; 20: 278-284 4 Breyer MD, Qi Z, Tchekneva E. Diabetic nephropathy: leveraging mouse genetics. Curr Opin Nephrol Hypertens 2006; 15: 227-232 5 Brosius FC, Alpers CE, Bottinger EP et al. Animal Models of Diabetic Complications Consortium. Mouse models of diabetic nephrophathy. J Am Soc Nephrol 2009; 20: 2503-2512
