Stronger Association of Common Variants in TCF7L2 Gene with Nonobese Type 2 Diabetes in the Latvian Population

I. Kalnina; K. Geldnere; L. Tarasova; L. Nikitina-Zake; R. Peculis; D. Fridmanis; V. Pirags; J. Klovins

doi:10.1055/s-0032-1306298

Experimental and Clinical Endocrinology & Diabetes, Inhaltsverzeichnis

Exp Clin Endocrinol Diabetes 2012; 120(08): 466-468
DOI: 10.1055/s-0032-1306298

Short Communication

Stronger Association of Common Variants in TCF7L2 Gene with Nonobese Type 2 Diabetes in the Latvian Population

I. Kalnina

¹Latvian Biomedical Research and Study Centre, Riga, Latvia

,

K. Geldnere

²Department of Endocrinology, Pauls Stradins Clinical University Hospital, Riga, Latvia

,

L. Tarasova

¹Latvian Biomedical Research and Study Centre, Riga, Latvia

,

L. Nikitina-Zake

¹Latvian Biomedical Research and Study Centre, Riga, Latvia

,

R. Peculis

¹Latvian Biomedical Research and Study Centre, Riga, Latvia

,

D. Fridmanis

¹Latvian Biomedical Research and Study Centre, Riga, Latvia

,

V. Pirags^*

¹Latvian Biomedical Research and Study Centre, Riga, Latvia

²Department of Endocrinology, Pauls Stradins Clinical University Hospital, Riga, Latvia

³Faculty of Medicine, University of Latvia, Riga, Latvia

,

J. Klovins^*

¹Latvian Biomedical Research and Study Centre, Riga, Latvia

› Institutsangaben

Abstract

Polymorphisms in the gene coding for transcription factor 7 like 2 (TCF7L2) are recognized as the strongest common genetic risk factors for type 2 diabetes (T2D) across multiple ethnicities. This study was conducted to evaluate an association between TCF7L2 variants and diabetes susceptibility in the population of Latvia. We genotyped 4 single nucleotide polymorphisms (SNP) rs7901695, rs7903146, rs11196205 and rs12255372 in 1 093 controls and 1 043 diabetic subjects. Association with T2D was found for 3 SNPs rs7901695, rs7903146 and rs12255372 in the whole sample (under an additive genetic model, the adjusted odds ratios (OR) were 1.26, 95% CI [1.08–1.48], P=0.003; OR=1.32, 95% CI [1.12–1.55], P=0.001 and OR=1.35, 95% CI [1.15–1.60], P=0.0004 respectively). In addition observed effects on T2D susceptibility for analysed SNPs were higher among subjects with BMI under 30 kg/m². The impact of TCF7L2 variation on T2D risk in Latvian population is compatible with that demonstrated by a range of studies conducted in various ethnic groups.

Key words

association study - polymorphism - T2D

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Referenzen

References
1 Billings LK, Florez JC. Ann N Y Acad Sci 2010; 1212: 59-77
2 Cauchi S, El Achhab Y, Choquet H et al. J Mol Med 2007; 85: 777-782
3 Ciganoka D, Balcere I, Kapa I et al. Eur J Endocrinol 2011; 165: 517-525
4 Purcell S, Neale B, Todd-Brown K et al. Am J Hum Genet 2007; 81: 559-575
5 Mayans S, Lackovic K, Lindgren P et al. Eur J Hum Genet 2007; 15: 342-346
6 Palmer ND, Hester JM, An SS et al. Diabetes 2010; 60: 662-668
7 Gaulton KJ, Nammo T, Pasquali L et al. Nat Genet 2010; 42: 255-259
8 Cauchi S, Nead KT, Choquet H et al. BMC Med Genet 2008; 9: 45
9 Lyssenko V, Lupi R, Marchetti P et al. J Clin Invest 2007; 117: 2155-2163
10 Schroner Z, Javorsky M, Tkacova R et al. Diabetes Obes Metab 2011; 13: 89-91