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J Neurol Surg A Cent Eur Neurosurg 2012; 73(02): 089-092
DOI: 10.1055/s-0032-1309064
Original Article
Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

Fibrillary Structure is Key for Hemostasis: A Similar Effect of Collagen Fleece and Oxidized Cellulose on Experimental Hemorrhagic Brain Injury[*]

E. Tessitore
1   Department of Neurosurgery, Geneva University Medical Center, Faculty of Medicine, University of Geneva, Switzerland
,
B. Schatlo
1   Department of Neurosurgery, Geneva University Medical Center, Faculty of Medicine, University of Geneva, Switzerland
,
C. Schaller
1   Department of Neurosurgery, Geneva University Medical Center, Faculty of Medicine, University of Geneva, Switzerland
,
C. Schonauer
2   Neurosurgical Unit, S. Maria delle Grazie, Naples, Italy
› Author Affiliations
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Publication History

Publication Date:
30 March 2012 (online)

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Fibrillary Structure is Key for Hemostasis: A Similar Effect of Collagen Fleece and Oxidized Cellulose on Experimental Hemorrhagic Brain InjuryCent Eur Neurosurg 2011; 72(S 01): e29-e29
DOI: 10.1055/s-0031-1275272

Abstract

Background The choice of the ideal hemostatic agent for intraoperative cerebral bleeding is under continuous debate. Our aim was to assess the influence of such materials on bleeding time in hemorrhagic cerebral contusions. We compared oxidized regenerated cellulose in fibrillar form (ORC) to microfibrillar collagen fleece (CF) in an experimental study.

Methods N=50 Sprague Dawley rats underwent a bilateral craniectomy. 3 separate standardized superficial cortical impacts were inflicted using a high-speed drill. Immediately after lesion placement, each of the 3 lesions was covered with (a) nothing (control), (b) ORC, or (c) CF. We observed the 3 lesions with a surgical microscope. The bleeding times were recorded for each cerebral lesion and compared using ANOVA test.

Results All traumatic lesions produced significant bleeding. The statistical analysis showed a clear reduction in bleeding time for groups treated with either ORC or CF compared to the control group. Lesions covered with ORC and CF showed no significant difference with regard to bleeding time.

Conclusions ORC and CF significantly reduce blood loss from hemorrhagic contusions. Our data suggest that they effectively reduce bleeding time. We advocate the use of hemostatic material for limiting bleeding from superficial cortical lesions.

Keywords

traumatic brain injury - local haemostasis - oxidized regenerated cellulose - collagen fleece - fibrillar form

* This article was originally published online in Central Eruopean Neurosurgery on May 19, 2011 (DOI: 10.1055/s-0031-1275272)


 

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