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Planta Med 2012; 78(12): 1378-1381
DOI: 10.1055/s-0032-1315000
Natural Product Chemistry
Letters
Georg Thieme Verlag KG Stuttgart · New York

Protein Tyrosine Phosphatase 1B (PTP1B)-Inhibiting Constituents from the Leaves of Syzygium polyanthum

Azis Saifudin
1   Division of Natural Products Chemistry, Institute of Natural Medicine, University of Toyama, Toyama, Japan
,
Ken Tanaka
2   Division of Pharmacognosy, Institute of Natural Medicine, University of Toyama, Toyama, Japan
,
Shigetoshi Kadota
1   Division of Natural Products Chemistry, Institute of Natural Medicine, University of Toyama, Toyama, Japan
,
Yasuhiro Tezuka
1   Division of Natural Products Chemistry, Institute of Natural Medicine, University of Toyama, Toyama, Japan
› Author Affiliations
Further Information

Publication History

received 25 April 2012
revised 01 June 2012

accepted 11 June 2012

Publication Date:
04 July 2012 (online)

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Abstract

A methanol extract of the leaves of Syzygium polyanthum (Wight) Walp. afforded four new acylbenzene derivatives (1–4) together with seven known compounds (5–11). The structures of 1–11 were elucidated by extensive spectroscopic methods and comparison with the literature data. The new compounds 1–3 and a known compound, campest-4-en-3-one (10), exhibited a significant protein tyrosine phosphatase 1B inhibitory activity with IC50 values of 13.1 ± 0.1, 5.77 ± 0.15, 4.01 ± 0.26, and 10.4 ± 0.5 µM, respectively. The inhibitory potency of the new compounds 2 and 3 was comparable to that of a positive control RK-682 (IC50, 5.51 ± 0.04 µM).

Key words

protein tyrosin phosphatase 1B - PTP1B - Indonesian medicinal plant - Syzygium polyanthum - Myrtaceae - daun salam - salam

Supporting Information

 

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