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Planta Med 2012; 78(15): 1702-1705
DOI: 10.1055/s-0032-1315209
Natural Product Chemistry
Letters
Georg Thieme Verlag KG Stuttgart · New York

Antiviral Triterpenoid Saponins from the Roots of Ilex asprella

Min Zhou  
1   State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, Peopleʼs Republic of China
2   Graduate University of Chinese Academy of Sciences, Beijing, Peopleʼs Republic of China
,
Min Xu  
1   State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, Peopleʼs Republic of China
,
Xiao-Xia Ma
1   State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, Peopleʼs Republic of China
4   Current address: Yunnan College of Traditional Chinese Medicine, Kunming, Peopleʼs Republic of China
,
Kai Zheng
3   Guangzhou Jinan Biomedicine Research & Development Center, Guangzhou, Peopleʼs Republic of China
,
Ke Yang
3   Guangzhou Jinan Biomedicine Research & Development Center, Guangzhou, Peopleʼs Republic of China
,
Chong-Ren Yang
1   State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, Peopleʼs Republic of China
,
Yi-Fei Wang
3   Guangzhou Jinan Biomedicine Research & Development Center, Guangzhou, Peopleʼs Republic of China
,
Ying-Jun Zhang
1   State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, Peopleʼs Republic of China
› Author Affiliations
Further Information

Publication History

received 12 June 2012
revised 09 July 2012

accepted 16 July 2012

Publication Date:
13 August 2012 (online)

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Abstract

Two new sulfur-containing triterpenoid saponins, asprellanosides A (1) and B (2), were isolated from the roots of Ilex asprella, together with 10 known compounds (3–12). An in vitro anti-HSV-1 activity test of the isolates (1–4, 6–7, and 9–12) showed that only asprellanoside A (1) and oblonganoside H (6) exhibited anti-HSV-1 activity with TIC values of 0.14 and 0.18 mM, respectively.

Key words

Ilex asprella - Aquifoliaceae - sulfur-containing triterpenoid saponins - asprellanosides A and B - antiviral

These authors contributed equally to this paper.


Supporting Information

 

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